[Pseudomonas aeruginosa and Proteus sensitivity to antibiotics and their combinations when cultured together]. / Chuvstvitel'nost' sinegnoinoi palochki i proteia, nakhodiashchikhsia v assotsiatsii drug s drugom, k antibiotikam i ikh kombinatsiiam.

Antibiotic sensitivity of Ps. aeruginosa associated with Proteus was lower than that of Ps. aeruginosa monocultures. This might result to some extent from interrelationships between Ps. aeruginosa and Proteus. Tobramycin, gentamicin and cephotaxim (claforan) proved to be the most active against Proteus cultures isolated from the associations. Eight combinations of gentamicin and tobramycin with carbenicillin, ampicillin or cephotaxim were tested. It was shown that the activity of all the combinations with respect to Ps. aeruginosa and Proteus was almost the same. No indifference or antagonism was observed. The combinations may be recommended for clinical use.

[Antibiotic sensitivity of different antigenic variants of Pseudomonas aeruginosa isolated in a hospital]. / Izuchenie chuvstvitel'nosti k antibiotikam razlichnykh antigennykh variantov Pseudomonas aeruginosa, vydelennykh v statsionare.

The serological typing of 96% of P. aeruginosa strains isolated in hospitals has been carried out by means of agglutinating sera, and the tendency towards the prevalence of the strains of group V (25.3%) and serovar O11 (18.1%) has been revealed. The determination of the antibiotic sensitivity of different variants has shown that the strains of groups I, V and serovar O11 possess pronounced resistance to a wide spectrum of antibiotics, their resistance to gentamycin and polymixin being higher than in the strains of other serotypes. The determination of antibiotic resistance can serve only as an additional test in the serological typing of P. aeruginosa.

[Sensitivity of clinical Proteus strains to antibiotics and their combinations]. / O chuvstvitel'nosti klinicheskikh shtammov proteia k antibiotikam i ikh kombinatsiiam.

In 1976 isolation of Proteus from wounds of patients with various purulent processes amounted to 14.5 per cent. Serotypes 0-10, 0-3 and H-3 predominated among the isolates. Sensitivity of 35 clinical strains of Proteus to 10 antibiotics, furagin and nevigramone was studied by the method of serial dilutions in liquid media. All the isolates were highly resistant to the antibiotics except gentamicin, furagin and nevigramone, the MIC of which for most of the strains was 3.12, 1.6-3.12 and 6.25-12.5 gamma/ml, respectively. The effect of 14 combinations of chemotherapeutics was also studied. The combinations of gentamicin with carbenicillin, gentamicin with ampicillin and monomycin with ampicillin proved to be most effective against the Proteus strains tested. The following combinations may be of practical value: monomycin + carbenicillin, kanamycin + ampicillin, kanamycin + carbenicillin, ampicillin + furagin, gentamicin + nevigramone. The combinations of carbenicillin with furagin and gentamicin with furagin were also rational.

[Prevention of suppuration in open fractures]. / Profilaktika nagnoenii pri otkrytykh perelomakh kostei

The authors have elaborated the complex of prophylactic measures against suppuration in treatment of open bone fractures, a special attention being given to the use of specific and nonspecific antistaphylococcic drugs: antibiotics of a wide spectrum of action, adsorbed staphylococcic anatoxin and staphyloccic polyvalent bacteriophage. Therapeutic measures and the results of their utilization are described.