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OBJECTIVE: To explore the value of procalcitonin (PCT) and brain natriuretic peptide (BNP) in predicting the prognosis of sepsis. METHODS: A total of 65 patients with sepsis received treatment in Deqing County People's Hospital from 2019 January and 2021 January and their data were collected retrospectively. Based on the survival and death of patients, 40 living patients were regarded as survival group, and 25 dead patients were regarded as the death group. PCT, BNP and, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores of sepsis patients in both groups on the first, third, and seventh days of admission were collected and compared respectively. ROC curve was utilized to calculate the relationship between the three indicators and prognosis. RESULTS: Compared with the death group, the PCT, BNP, and APACHE II scores in the survival group were lower on the first, third, and seventh days (P < 0.05). On the first, third, and seventh day, the AUC of PCT were 0.768, 0.829, and 0.831; the AUC of BNP were 0.771, 0.805, and 0.848; the AUC of APACHE II were 0.891, 0.809, and 0.974 (P < 0.05). CONCLUSION: The level of plasma PCT and BNP in sepsis patients was increased, and they are positively correlated with the severity of the disease, which can be used as an indicator of bad prognosis of sepsis patients.
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OBJECTIVES: The depressed heart function is the main complication to cause death of septic patients in clinic. It is urgent to find effective interventions for this intractable disease. In this study, we investigated whether butyrate could be protective for heart against sepsis and the underlying mechanism. METHODS: Mice were randomly divided into three groups. Model group challenged with LPS (30 mg/kg, i.p.) only. Butyrate group received butyrate (200 mg/kg·d) for 3days prior to LPS administration (30 mg/kg). Normal group received saline only. 6h and 12h after LPS administration were chosen for detection the parameters to estimate the effects or mechanism of butyrate pretreatment on heart of sepsis. RESULTS: The data showed that septic heart depression was attenuated by butyrate pretreatment through improvement of heart function depression (P<0.01) and reduction of morphological changes of myocardium. The overexpression of proinflammatory factors, TNF-α, IL-6 and LTB4, in heart tissues induced by sepsis was significantly alleviated by butyrate pretreatment (P<0.01). As oxidative stress indicators, SOD and CAT activity, and MDA content in heart were deteriorated by LPS challenge, which was noticeably ameliorated by butyrate pretreatment (P<0.01 or P<0.05). CONCLUSIONS: In conclusion, pretreatment with butyrate attenuated septic heart depression via anti-inflammation and anti-oxidation.
