Cryptoporic acid S, a new drimane-type sesquiterpene ether of isocitric acid from the fruiting bodies of Cryptoporus volvatus.

A new drimane-type sesquiterpene with an isocitric acid moiety, cryptoporic acid S (1), together with six known compounds, cryptoporic acid D (2), ß-sitosterol (3), ß-daucosterol (4), stigmast-4-en-3-one (5), ergosterol (6), and (22E,24R)-ergosta-7,22-diene-3ß,5α,6ß-triol (7), was isolated from the fruiting bodies of Cryptoporus volvatus. The structures of these compounds were established on the basis of UV, IR, MS, 1D and 2D NMR analysis. In the meanwhile, compounds 1 and 2 were evaluated for antioxidant activity using the methods of 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity (DPPH-RSA) and ferric reducing antioxidant power (FRAP) assay, and they exhibited moderate antioxidant activities.

[Chemical constituents contained in aerial parts of Emilia sonchifolia].

OBJECTIVE: To study the chemical constituents contained in ethanol extracts from aerial parts of Emilia sonchifolia. METHOD: The compounds were separated and purified with various chromatographic techniques, and their structures were identified on the basis of physicochemical properties and spectral data. RESULT: Fifteen compounds were separated from ethyl acetate fraction of 90% ethanolic extract and identified as rhamnetin (1), isorhamnetin (2), quercetin (3), luteolin (4), tricin-7-O-beta-D-glucopyranoside (5), 8-(2"-pyrrolidinone-5"-yl) -quercetin (6), 5, -2', 6'-trihydroxy-7, 8-dimethoxyflavone-2'-O-beta-D-glucopyranoside (7), succinic acid (8), fumaric acid (9), p-hydroxybenzoic acid (10), 4-hydroxy isophthalic acid (11), 3, 4-dihydroxycinnamic acid (12), esculetin (13), isowedelolactone (14) and uracil (15), respectively. CONCLUSION: All compounds except compound 3 were separated from this genus for the first time.

[Studies on the chemical constituents of the aerial part of Cimicifuga foetida L].

AIM: To look for new active constituents from the aerial part of Cimicifuga foetida L. METHODS: Various column chromatographic techniques were used for the isolation and purification of the principles. The structures were elucidated on the basis of spectral data and chemical evidences. RESULTS: Five 9,19-cycloartane triterpenoid saponins and one sitosterol saponin were obtained and identified as cimifoetiside I [12 beta-hydroxycimigenol-3-O-beta-D-galactoyranoside, (1)], cimifoetiside II [(23R,24R) cimigenol-3-O-beta-D-galactopyranoside, (2)], cimigenol-3-O-beta-D-galactopyranoside (3), 12 beta-hydroxycimigenol-3-O-beta-D-xylopyranoside (4), 12 beta-hydroxycimigenol-3-O-alpha-L-arabinopyranoside (5), daucosterol (6). CONCLUSION: Compounds 1 and 2 are new and compounds 4 and 5 were isolated from this plant for the first time.

[Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida].

OBJECTIVE: To find new active constituents from Rhizome of Cimicifuga foetida. METHOD: Various column chromatographic techniques were employed for isolation and purification. The structures were elucidated on the basis of spectral and chemical evidences. RESULT: Four triterpenoid compounds were isolated and identified as 7,8-didehydro-27-deoxyactein(1), 24-O-acetylshengmanol-3-O-beta-D-xyl (23R, 24R)[2], cimigenol(3), cimigenol-3-O-beta-D-xyl(4). CONCLUSION: Compound 1 is a new compound, 2-4 were obtained from this medicinal material for the first time. The antiosteoporosis activity screening in vitro(by the method of SRB) indicates that Compounds 1, 2 and 4 can promote the proliferation for rat Osteoblastoma cell line (UMR106) at the concentration of 10(-9) kg.L-1.

[Studies on the new triterpenoid saponin of the aerial part of Cimicifuga foetida].

OBJECTIVE: To find new active constituents from the aerial part of Cimicifuga foetida. METHOD: Various column chromatographic techniques were used for the isolation and purification of the principles. The structures were elucidated on the basis of spectral data and chemical evidences. RESULT: Four 9,19-cycloartane triterpenoid saponins were obtained and identified as Cimifoetiside III (25-anhydrocimigenol-3-O-beta-D-galactopyranoside, 1), 25-O-acetyl-cimigenol xylopyranoside (2), 25-O-acetyl-cimigenol galactopyranoside (3), 7 beta-hydrocimigenol xylopyranoside (4). CONCLUSION: Compound 1 is new and compound 4 was isolated from this plant for the first time.

[Studies on the triterpenoid constituents from the aerial part of Cimicifuga foetida L].

AIM: To look for new active constituents from the aerial part of Cimicifuga foetida L. METHODS: Various column chromatographic techniques were used for the isolation and purification of the ingredients. The structure were elucidated on the basis of spectral evidences and chemical reaction. RESULTS: Five compounds were obtained and identified as 23-O-acetylshengmanol-3-O-alpha-L-arabinopyranoside (1), 23-O-acetylshengmanol-3-O-beta-D-xylopyranoside (2), 25-anhydrocimigenol-3-O-beta-D-xylopyranoside (3), cimigenol-3-O-alpha-L-arabinopyranoside (4), cimigenol-3-O-beta-D-xylopyranoside (5). CONCLUSION: Compound 1 is a new compound, and compounds 2 and 4 were isolated from this plant for the first time.

[Studies on the phenolic acid constituents from Chinese medicine "sheng-ma", rhizome of Cimicifuga foetida L].

AIM: To look for new active constituents from Chinese medicine "Sheng-ma", rhizome of Cimicifuga foetida L. METHODS: The compounds were separated and purified by chromatography on silica gel and Sephadex LH-20. Their structures were determined by spectral analysis and chemical reaction. RESULTS: Eight compounds were obtained and identified as cimicifugic acid (1), esculetin (2), caffeic acid methyl ester (3), 4-O-acetyl-caffeic acid (4), sinapic acid (5), caffeic acid (6), ferulic acid (7), isoferulic acid (8). CONCLUSION: Compound 1 is a new compound, and compounds 2-7 were isolated from this plant for the first time.