Fecal microbiota transplantation for patients with irritable bowel syndrome: A meta-analysis protocol.

Irritable bowel syndrome (IBS) is a common functional bowel disease characterized by chronic or recurrent abdominal pain, bloating, constipation, and diarrhea. Many patients with IBS have a poor quality of life due to abdominal discomfort, diarrhea, constipation, and the presence of other diseases. At present, intestinal motility inhibitors, adsorbents, astringents, intestinal mucosal protective agents, and antidepressants have been combined to treat IBS, but the treatment process is long, which results in a large economic burden to patients. Fecal microbiota transplantation (FMT) is a treatment involving the transplantation of functional bacteria from healthy human feces into the gastrointestinal tract of patients; thus, replacing the intestinal flora and modulating intestinal and extra-intestinal diseases. In recent years, the efficacy and economic benefits of FMT in the treatment of IBS have received increasing attention from researchers.A search for randomized controlled trials (RCTs) on treating IBS with FMT will be performed using 9 databases, including PubMed, the Cochrane Library, Embase, ClinicalTrails, China National Knowledge Infrastructure, Sino Med, ScienceDirect, VIP, and Wanfang Data. Two reviewers will independently screen data extraction studies and assess study quality and risk of bias. The risk of bias for each RCT will be assessed against the Cochrane Handbook standards to assess methodological quality. RevMan V.5.3 software will be used to calculate data synthesis when meta-analysis is allowed.This study will provide a high-quality synthesis of existing evidence on the effectiveness and safety of FMT in the treatment of IBS.This study will determine if FMT is an effective and safe intervention for IBS.PROSPERO registration number is PROSPERO CRD42018108080.

[ДX11538a: The remnant Dunhuang Codex's of the Classic of Difficult Issues collected in Russia].

The finalized edition of the Classic of Difficult Issues was collected by Yang Xuancao in the early Tang dynasty and is the only extant version so far. No earlier versions were seen since then. However, ДX11538a, one of the Russian Collection of DUNHUANG remnant papers, was verified to be a segment of the said Classic. Compared with the now circulated edition, this version is randomly arranged and irregular in its text. Even so, it still reflects, to some extent, the old picture of that ancient Classic, with some points even better than the latter. This version is significant to the researchers of this Classic even today.

[Analysis of the time recorded in Canggongzhuan].

Shiji·Bianquecanggong Liezhuan is the first biography in official history. The doctor of the Western Han dynasty-Chunyu Yi, recorded in Canggongzhuan, was an actual historical figure. Recordings about his time of life, social background and medical stories were full and accurate. But the time of events recorded in that book was inaccurate. After analysis of related material, it transpired that Chun Yuyi was put into jail in the 13(th) year of the Emperor Hanwen Period, not the 4(th) year, and he answered the questions of the Emperor Hanwen in the 13(rd) ∼ 14(th) year when he was 39 ∼ 40 years old.

[The supplementation and correction of the 'Interpretive outline of Dunhuang medical literature' hidden in Russia].

'Interpretive outline of Dunhuang medical literature', hidden in Russia, which was written by Li Ying-cun, was the required reading book for the researchers of Dunhuang medical literature. By carefully reading this book and contrasting it with the original volumes, we can find that there are still careless omissions in the aspects of knowledge, sentences and phrases and interpretations in this book. As a result, we supplement and correct it by combining other relevant literature.