Lower-level oculomotor deficits in schizophrenia during multi-line reading: Evidence from return-sweeps.

Reading fluency deficits in schizophrenia (Sz) have been attributed to dysfunction in both lower-level, oculomotor processing and higher-level, lexical processing, according to the two-hit deficit model. Given that prior work examining reading deficits in individuals with Sz has primarily focused on single-line and single-word reading tasks, eye movements that are unique to passage reading, such as return-sweep saccades, have not yet been examined in Sz. Return-sweep saccades are large eye movements that are made when readers move from the end of one line to the beginning of the next line during natural passage reading. Examining return-sweeps provides an opportunity to examine lower-level, oculomotor deficits during reading under circumstances when upcoming higher-level, lexical information is not available for visual processing because visual acuity constraints do not permit detailed lexical processing of line-initial words when return-sweeps are programmed. To examine the source of reading deficits in Sz, we analysed an existing data set in which participants read multi-line passages with manipulations to line spacing. Readers with Sz made significantly more return-sweep targeting errors followed by corrective saccades compared with healthy controls. Both groups showed similar effects of line spacing on return-sweep targeting accuracy, suggesting similar sensitivities to visual crowding during reading. Furthermore, the patterns of fixation durations in readers with Sz corroborate prior work indicating reduced parafoveal processing of upcoming words. Together, these findings suggest that lower-level visual and oculomotor dysfunction contribute to reading deficits in Sz, providing support for the two-hit deficit model.

Music reading expertise affects visual change detection: Evidence from a music-related flicker paradigm.

To study the mechanisms and boundary conditions of expertise effects on change detection, we introduced a novel music-related variant of the flicker paradigm. Specifically, we monitored the eye movements of expert musicians (with 10 years of music experience) and non-musicians (who could not read music) while they located changes across two rapidly alternating versions of a music score, with a blank screen presented between each screen change. Relative to the non-musicians, experts were faster at change detection, with shorter fixations and larger saccade amplitudes. Expertise effects on accuracy and saccade amplitude were magnified for visually complex relative to simple music scores. Consistent with the assumptions of chunking and template theories of expertise, our results suggest that expert musicians can use chunking (i.e., perceptual grouping) mechanisms to facilitate perceptual encoding during change detection.

Are emojis processed like words?: Eye movements reveal the time course of semantic processing for emojified text.

Emojis have many functions that support reading. Most obviously, they convey semantic information and support reading comprehension (Lo, CyberPsychology & Behavior, 11[5], 595-597, 2008; Riordan, Computers in Human Behavior, 76, 75-86, 2017b). However, it is undetermined whether emojis recruit the same perceptual and cognitive processes for identification and integration during reading as do words. To investigate whether emojis are processed like words, we used eye tracking to examine the time course of semantic processing of emojis during reading. Materials consisted of sentences containing a target word (e.g., coffee in the sentence "My tall coffee is just the right temperature") when there was no emoji present and when there was a semantically congruent (i.e., synonymous) emoji (e.g., the cup of coffee emoji, ) or an incongruent emoji (e.g., the beer mug emoji, ) present at the end of the sentence. Similar to congruency effects with words, congruent emojis were fixated for shorter periods and were less likely to be refixated than were incongruent emojis. In addition, congruent emojis were more frequently skipped than incongruent emojis, which suggests that semantic aspects of emoji processing begin in the parafovea. Finally, the presence of an emoji, relative to its absence increased target-word skipping rates and reduced total time on target words. We discuss the implications of our findings for models of eye-movement control during reading.

Neurophysiological, Oculomotor, and Computational Modeling of Impaired Reading Ability in Schizophrenia.

Schizophrenia (Sz) is associated with deficits in fluent reading ability that compromise functional outcomes. Here, we utilize a combined eye-tracking, neurophysiological, and computational modeling approach to analyze underlying visual and oculomotor processes. Subjects included 26 Sz patients (SzP) and 26 healthy controls. Eye-tracking and electroencephalography data were acquired continuously during the reading of passages from the Gray Oral Reading Tests reading battery, permitting between-group evaluation of both oculomotor activity and fixation-related potentials (FRP). Schizophrenia patients showed a marked increase in time required per word (d = 1.3, P < .0001), reflecting both a moderate increase in fixation duration (d = .7, P = .026) and a large increase in the total saccade number (d = 1.6, P < .0001). Simulation models that incorporated alterations in both lower-level visual and oculomotor function as well as higher-level lexical processing performed better than models that assumed either deficit-type alone. In neurophysiological analyses, amplitude of the fixation-related P1 potential (P1f) was significantly reduced in SzP (d = .66, P = .013), reflecting reduced phase reset of ongoing theta-alpha band activity (d = .74, P = .019). In turn, P1f deficits significantly predicted increased saccade number both across groups (P = .017) and within SzP alone (P = .042). Computational and neurophysiological methods provide increasingly important approaches for investigating sensory contributions to impaired cognition during naturalistic processing in Sz. Here, we demonstrate deficits in reading rate that reflect both sensory/oculomotor- and semantic-level impairments and that manifest, respectively, as alterations in saccade number and fixation duration. Impaired P1f generation reflects impaired fixation-related reset of ongoing brain rhythms and suggests inefficient information processing within the early visual system as a basis for oculomotor dyscontrol during fluent reading in Sz.

Expertise effects on attention and eye-movement control during visual search: Evidence from the domain of music reading.

Experts in many domains use their domain-specific knowledge to rapidly locate relevant information. To explore this ability in music reading, we contrasted the eye movements of 30 expert musicians (with at least 10 years of music reading training) and 30 non-musicians (who could not read music) while they completed a visual search task that required them to match a section of a complex piano music score (i.e., the search template) to its identical counterpart within a larger music score (i.e., the search array). Critically, both the search template and array were presented simultaneously throughout each trial in the experiment, which allowed for visual comparisons between the search template and the array. Relative to the non-musicians, the experts had higher accuracy and also spent more time looking at the relevant regions and less time looking at irrelevant regions. Also, as evidence that the experts and non-musicians adopted qualitatively different search strategies, the experts spent more time than non-musicians looking at the search template at the beginning of the trial, and the experts returned to this region less often than non-musicians. Taken together, our results indicate that experts use domain-specific knowledge in the form of "chunks" (Chase & Simon, 1973a, 1973b) and "templates" (Gobet & Simon, 1996b, 2000) to acquire accurate representations of highly complex search templates.

The time course of age-of-acquisition effects on eye movements during reading: Evidence from survival analyses.

Adults process words that are rated as being learned earlier in life faster than words that are rated as being acquired later in life. This age-of-acquisition (AoA) effect has been observed in a variety of word-recognition tasks when word frequency is controlled. AoA has also previously been found to influence fixation durations when words are embedded into sentences and eye movements are recorded. However, the time course of AoA effects during reading has been inconsistent across studies. The current study further explored the time course of AoA effects on distributions of first-fixation durations during reading. Early and late acquired words were embedded into matched neutral sentence frames. Participants read the sentences while their eye movements were recorded. AoA effects were observed in both early and late fixation duration measures, suggesting that AoA has an early and long-lasting effect on word-recognition processes during reading. Survival analysis revealed that the earliest discernable effect of AoA on distributions of first-fixation durations emerged beginning at 158 ms. This rapid influence of AoA was confirmed through the use of Vincentile plots, which demonstrated that the effect of AoA occurred early and was relatively consistent across the distribution of fixations. This pattern of results provides support for the direct lexical-control hypothesis, as well as the viewpoint that AoA may exert an influence at multiple loci within the mental lexicon.

The Holistic Processing Account of Visual Expertise in Medical Image Perception: A Review.

In the field of medical image perception, the holistic processing perspective contends that experts can rapidly extract global information about the image, which can be used to guide their subsequent search of the image (Swensson, 1980; Nodine and Kundel, 1987; Kundel et al., 2007). In this review, we discuss the empirical evidence supporting three different predictions that can be derived from the holistic processing perspective: Expertise in medical image perception is domain-specific, experts use parafoveal and/or peripheral vision to process large regions of the image in parallel, and experts benefit from a rapid initial glimpse of an image. In addition, we discuss a pivotal recent study (Litchfield and Donovan, 2016) that seems to contradict the assumption that experts benefit from a rapid initial glimpse of the image. To reconcile this finding with the existing literature, we suggest that global processing may serve multiple functions that extend beyond the initial glimpse of the image. Finally, we discuss future research directions, and we highlight the connections between the holistic processing account and similar theoretical perspectives and findings from other domains of visual expertise.

On using distributional analysis techniques for determining the onset of the influence of experimental variables.

Much of the investigation of eye-movement control in visual cognition has focused on the influence of experimental variables on mean fixation durations. In the present paper we explored the convergence between two distributional analysis techniques that were recently introduced in this domain. First, Staub, White, Drieghe, Hollway and Rayner, (2010) proposed fitting the ex-Gaussian distribution to individual participants' data in order to ascertain whether a variable has a rapid or a slow influence on fixation durations. Second, the Divergence Point Analysis (DPA) procedure was introduced by Reingold, Reichle, Glaholt and Sheridan (2012, Reingold & Sheridan, 2014) in order to determine more precisely the earliest discernible impact of a variable on the distribution of fixation durations by contrasting survival curves across two experimental conditions and determining the point at which the two curves begin to diverge. In the present paper we introduced a new version of the DPA procedure which is based on ex-Gaussian fitting. We evaluated this procedure by re-analysing data obtained in previous empirical investigations as well as by conducting a simulation study. We demonstrated that the new ex-Gaussian DPA technique produced estimates that were consistent with estimates produced by prior versions of DPA procedure, and in the present simulation, the ex-Gaussian DPA procedure produced somewhat more accurate individual participant divergence point estimates. Based on the present findings we also suggest guidelines for best practices in the use of DPA techniques.

Chess players' eye movements reveal rapid recognition of complex visual patterns: Evidence from a chess-related visual search task.

To explore the perceptual component of chess expertise, we monitored the eye movements of expert and novice chess players during a chess-related visual search task that tested anecdotal reports that a key differentiator of chess skill is the ability to visualize the complex moves of the knight piece. Specifically, chess players viewed an array of four minimized chessboards, and they rapidly searched for the target board that allowed a knight piece to reach a target square in three moves. On each trial, there was only one target board (i.e., the "Yes" board), and for the remaining "lure" boards, the knight's path was blocked on either the first move (the "Easy No" board) or the second move (i.e., "the Difficult No" board). As evidence that chess experts can rapidly differentiate complex chess-related visual patterns, the experts (but not the novices) showed longer first-fixation durations on the "Yes" board relative to the "Difficult No" board. Moreover, as hypothesized, the task strongly differentiated chess skill: Reaction times were more than four times faster for the experts relative to novices, and reaction times were correlated with within-group measures of expertise (i.e., official chess ratings, number of hours of practice). These results indicate that a key component of chess expertise is the ability to rapidly recognize complex visual patterns.

Character-complexity effects in Chinese reading and visual search: A comparison and theoretical implications.

Three eye-movement experiments were conducted to examine how the complexity of characters in Chinese words (i.e., number of strokes per character) influences their processing and eye-movement behaviour. In Experiment 1, English speakers with no significant knowledge of Chinese searched for specific low-, medium-, and high-complexity target characters in a multi-page narrative containing characters of varying complexity (3-16 strokes). Fixation durations and skipping rates were influenced by the visual complexity of both the target characters and the characters being searched even though participants had no knowledge of Chinese. In Experiment 2, native Chinese speakers performed the same character-search task, and a similar pattern of results was observed. Finally, in Experiment 3, a second sample of native Chinese speakers read the same text used in Experiments 1 and 2, with text characters again exhibiting complexity effects. These results collectively suggest that character-complexity effects on eye movements may not be due to lexical processing per se but may instead reflect whatever visual processing is required to know whether or not a character corresponds to an episodically represented target. The theoretical implications of this for our understanding of normal reading are discussed.

Attention and eye-movement control in reading: The selective reading paradigm.

We introduced a novel paradigm for investigating covert attention and eye-movement control in reading. In 2 experiments, participants read sentence words (shown in blue color) while ignoring interleaved distractor strings (shown in orange color). Each single-line text display contained a target word and a critical distractor. Critical distractors were located just prior to the target in the text and were either words or symbol strings (e.g., @#%&). Target word availability for parafoveal processing (i.e., preview validity) was also manipulated. The results indicated much shallower processing of distractors than targets, and this pattern was more pronounced for symbol than word distractors. The influences of word frequency and fixation location on first-pass fixation durations on distractors were dramatically different than the well-documented pattern obtained in normal reading. Robust preview benefits were demonstrated both when the critical distractors were fixated and when the critical distractors were skipped. Finally, with the exception of larger preview benefits that were obtained in the condition in which the target and critical distractor were identical, the magnitude of the preview effect was largely unaffected by the nature of the critical distractor. Implications of the present paradigm and findings to the study of eye-movement control in reading are discussed. (PsycINFO Database Record

Why does removing inter-word spaces produce reading deficits? The role of parafoveal processing.

To examine the role of inter-word spaces during reading, we used a gaze-contingent boundary paradigm to manipulate parafoveal preview (i.e., valid vs. invalid preview) in a normal text condition that contained spaces (e.g., "John decided to sell the table") and in an unsegmented text condition that contained random numbers instead of spaces (e.g.,"John4decided8to5sell9the7table"). Preview effects on mean first-fixation durations were larger for normal than unsegmented text conditions, and survival analyses revealed a delay in the onset of both preview validity and word-frequency effects on first-fixation durations for unsegmented relative to normal text. Taken together with simulations that were conducted using the E-Z Reader model, the present findings indicated that unsegmented text deficits reflect disruptions to both parafoveal processing and lexical processing. We discuss the implications of our results for models of eye-movement control.

An Analysis of the Time Course of Lexical Processing During Reading.

Reingold, Reichle, Glaholt, and Sheridan (2012) reported a gaze-contingent eye-movement experiment in which survival-curve analyses were used to examine the effects of word frequency, the availability of parafoveal preview, and initial fixation location on the time course of lexical processing. The key results of these analyses suggest that lexical processing begins very rapidly (after approximately 120 ms) and is supported by substantial parafoveal processing (more than 100 ms). Because it is not immediately obvious that these results are congruent with the theoretical assumption that words are processed and identified in a strictly serial manner, we attempted to simulate the experiment using the E-Z Reader model of eye-movement control (Reichle, 2011). These simulations were largely consistent with the empirical results, suggesting that parafoveal processing does play an important functional role by allowing lexical processing to occur rapidly enough to mediate direct control over when the eyes move during reading.

Estimating the divergence point: a novel distributional analysis procedure for determining the onset of the influence of experimental variables.

The divergence point analysis procedure is aimed at obtaining an estimate of the onset of the influence of an experimental variable on response latencies (e.g., fixation duration, reaction time). The procedure involves generating survival curves for two conditions, and using a bootstrapping technique to estimate the timing of the earliest discernible divergence between curves. In the present paper, several key extensions for this procedure were proposed and evaluated by conducting simulations and by reanalyzing data from previous studies. Our findings indicate that the modified versions of the procedure performed substantially better than the original procedure under conditions of low experimental power. Furthermore, unlike the original procedure, the modified procedures provided divergence point estimates for individual participants and permitted testing the significance of the difference between estimates across conditions. The advantages of the modified procedures are illustrated, the theoretical and methodological implications are discussed, and promising future directions are outlined.

Expert vs. novice differences in the detection of relevant information during a chess game: evidence from eye movements.

The present study explored the ability of expert and novice chess players to rapidly distinguish between regions of a chessboard that were relevant to the best move on the board, and regions of the board that were irrelevant. Accordingly, we monitored the eye movements of expert and novice chess players, while they selected white's best move for a variety of chess problems. To manipulate relevancy, we constructed two different versions of each chess problem in the experiment, and we counterbalanced these versions across participants. These two versions of each problem were identical except that a single piece was changed from a bishop to a knight. This subtle change reversed the relevancy map of the board, such that regions that were relevant in one version of the board were now irrelevant (and vice versa). Using this paradigm, we demonstrated that both the experts and novices spent more time fixating the relevant relative to the irrelevant regions of the board. However, the experts were faster at detecting relevant information than the novices, as shown by the finding that experts (but not novices) were able to distinguish between relevant and irrelevant information during the early part of the trial. These findings further demonstrate the domain-related perceptual processing advantage of chess experts, using an experimental paradigm that allowed us to manipulate relevancy under tightly controlled conditions.

A three-step process to facilitate the annulation of polycyclic aromatic hydrocarbons.

A new efficient three-step process to annulate polycyclic aromatic hydrocarbons (PAHs) has been developed, providing access to PAHs with saturated rings that under current chemical methods would be difficult to produce in an efficient manner. This method relies on a palladium-catalyzed cross-coupling reaction of various brominated PAHs with cyclohexanone to yield α-arylated ketones, which are converted to regiospecific vinyl triflates and cyclized by a palladium-catalyzed intramolecular arene-vinyl triflate coupling to produce PAHs with incorporated saturated rings or "tetrahydroindeno-annulated" PAHs.

The mechanisms and boundary conditions of the Einstellung effect in chess: evidence from eye movements.

In a wide range of problem-solving settings, the presence of a familiar solution can block the discovery of better solutions (i.e., the Einstellung effect). To investigate this effect, we monitored the eye movements of expert and novice chess players while they solved chess problems that contained a familiar move (i.e., the Einstellung move), as well as an optimal move that was located in a different region of the board. When the Einstellung move was an advantageous (but suboptimal) move, both the expert and novice chess players who chose the Einstellung move continued to look at this move throughout the trial, whereas the subset of expert players who chose the optimal move were able to gradually disengage their attention from the Einstellung move. However, when the Einstellung move was a blunder, all of the experts and the majority of the novices were able to avoid selecting the Einstellung move, and both the experts and novices gradually disengaged their attention from the Einstellung move. These findings shed light on the boundary conditions of the Einstellung effect, and provide convergent evidence for Bilalic, McLeod, & Gobet (2008)'s conclusion that the Einstellung effect operates by biasing attention towards problem features that are associated with the familiar solution rather than the optimal solution.

A further examination of the lexical-processing stages hypothesized by the E-Z Reader model.

Participants' eye movements were monitored while they read sentences in which high- and low-frequency target words were presented normally (i.e., the normal condition) or with either reduced stimulus quality (i.e., the faint condition) or alternating lower- and uppercase letters (i.e., the case-alternated condition). Both the stimulus quality and case alternation manipulations interacted with word frequency for the gaze duration measure, such that the magnitude of word frequency effects was increased relative to the normal condition. However, stimulus quality (but not case alternation) interacted with word frequency for the early fixation time measures (i.e., first fixation, single fixation), whereas case alternation (but not stimulus quality) interacted with word frequency for the later fixation time measures (i.e., total time, go-past time). We interpret this pattern of results as evidence that stimulus quality influences an earlier stage of lexical processing than does case alternation, and we discuss the implications of our results for models of eye movement control during reading.

Perceptually specific and perceptually non-specific influences on rereading benefits for spatially transformed text: evidence from eye movements.

The present study used eye tracking methodology to examine rereading benefits for spatially transformed text. Eye movements were monitored while participants read the same target word twice, in two different low-constraint sentence frames. The congruency of perceptual processing was manipulated by either applying the same type of transformation to the word during the first and second presentations (i.e., the congruent condition), or employing two different types of transformations across the two presentations of the word (i.e., the incongruent condition). Perceptual specificity effects were demonstrated such that fixation times for the second presentation of the target word were shorter for the congruent condition compared to the incongruent condition. Moreover, we demonstrated an additional perceptually non-specific effect such that second reading fixation times were shorter for the incongruent condition relative to a baseline condition that employed a normal typography (i.e., non-transformed) during the first presentation and a transformation during the second presentation. Both of these effects (i.e., perceptually specific and perceptually non-specific) were similar in magnitude for high and low frequency words, and both effects persisted across a 1 week lag between the first and second readings. We discuss the present findings in the context of the distinction between conscious and unconscious memory, and the distinction between perceptually versus conceptually driven processing.

Direct lexical control of eye movements in reading: evidence from a survival analysis of fixation durations.

Participants' eye movements were monitored in an experiment that manipulated the frequency of target words (high vs. low) as well as their availability for parafoveal processing during fixations on the pre-target word (valid vs. invalid preview). The influence of the word-frequency by preview validity manipulation on the distributions of first fixation duration was examined by using ex-Gaussian fitting as well as a novel survival analysis technique which provided precise estimates of the timing of the first discernible influence of word frequency on first fixation duration. Using this technique, we found a significant influence of word frequency on fixation duration in normal reading (valid preview) as early as 145ms from the start of fixation. We also demonstrated an equally rapid non-lexical influence on first fixation duration as a function of initial landing position (location) on target words. The time-course of frequency effects, but not location effects was strongly influenced by preview validity, demonstrating the crucial role of parafoveal processing in enabling direct lexical control of reading fixation times. Implications for models of eye-movement control are discussed.