Treatment of congenital ichthyosis with acitretin: a case report.

The authors assessed the clinical efficacy, tolerability and safety of acitretin in a patient with ichthyosis. A newborn infant with ichthyosis who presented at birth with collodion baby appearance, was treated with acitretin. A moderate response to acitretin therapy (1 mg/kg/day) administered for 6 months was observed, with improvement in cutaneous lesions. Clinical improvement was achieved shortly after treatment. The treatment resulted in a satisfactory improvement in the skin condition of the case. The tolerance to the drug was good. Side effects were not observed. The oral acitretin treatment is efficient in severe congenital ichthyosis.

[Clinico-pathogenetic aspects of infectious toxicosis in infants caused by acute pneumonia]. / Kliniko-patogeneticheskie aspekty infektsionnogo toksikoza u detei rannego vozrasta, vyzvannogo ostrymi pnevmoniiami.

Altogether 101 children under one year of age with infectious toxicosis due to acute pneumonia were examined for the clinical, roentgenomorphological and biochemical aspects of the given condition. The clinical aspects were delineated on the basis of the universal status covered by the formalized case report. The biochemical processes were analyzed according to the content of peroxidation products of membrane lipids, the concentration of hydrogen peroxide, phospholipase activity, antioxidant and antiperoxide defence of the blood as well as according to the physical constants of red blood cell membranes. A direct relationship was discovered between the clinical picture (the degree of toxicosis) and membranopathological processes. The data obtained make it possible to conceive the model of infectious toxicosis as a membranopathological one, induced by the syndrome of the deficiency of antioxidant and antiperoxide enzymes.

[Clinical value of studying phospholipids in young children with acute pneumonia]. / Klinicheskoe znachenie issledovaniia fosfolipidov pri ostroi tiazhelo protekaiushchei pnevmonii u detei rannego vozrasta.

A study was made of phospholipid metabolism in 268 children aged 1 month to 3 years, who were in a critical condition consequent on acute complicated pneumonia. Unbalance of that type metabolism was revealed. It consisted in intensive accumulation of lysophosphatidylcholine, sphingomyelin in the stroma of red blood cells and in a decrease of their pool in the blood plasma as well as in a reduction of the content of phosphatidylserine and phosphatidylethanolamine towards the plasma pool. The bronchial secretion was established to have an elevated content of malonic dialdehyde, diene conjugates and active phospholipases. The indicated membrane destabilizing processes occurring in patients with acute complicated pneumonia, who are in urgent conditions, dictate the necessity of including antioxidants and membrane stabilizers into the multimodality treatment of the disease.

[Changes in the activity of antioxidant enzymes in ischemia and subsequent reperfusion of the myocardium]. / Izmenenie aktivnosti "antioksidantnykh" fermentov pri ishemii i posleduiushchei reperfuzii miokarda.

Transitory coronary failure of the myocardium was accompanied by a considerable reduction in the activity of superoxide dismutase, glutathione peroxidase and glutathione transferase, with the activity of the enzymes under study being not different in the ischemized and distant from ischemia zones of the myocardium. Reperfusion did influence the activity of superoxide dismutase and glutathione peroxidase after 10 and 40 minutes of ischemia, whereas following 120 minutes of ischemia the activity of superoxide dismutase ascended after 10 and 40 minutes of reperfusion while the activity of glutathione peroxidase remained unchanged.