Immunohistochemistry: An indispensable aid in diagnosis and management of infantile myofibroblastoma.

Myofibroma is a benign tumor of myofibroblasts occurring commonly in infants and children. It can occur as a solitary lesion or as multiple lesions in the soft tissues or intraosseously. The presence of the solitary lesion is common in the soft tissues of the head-and-neck region but rare in jawbones. Histologically, it has a biphasic pattern of presentation and mimics spindle cell tumors. Immunohistochemistry is essential for its confirmatory diagnosis. This article describes a case of this rare lesion presenting as a solitary lesion in the left body of the mandible in a 7-month-old boy baby. The diagnostic and therapeutic challenges have been discussed.

Primary intraosseous squamous cell carcinoma ex-odontogenic cyst.

Squamous cell carcinomas of the oral cavity are quite common, but primary intraosseous squamous cell carcinomas (PIOSCCs) are rare. Their origin from lining of different odontogenic cysts has been documented. More than 50% of such cases have been reported to occur in periapical inflammatory cysts, and less than 10 cases are reported to arise from odontogenic keratocyst (OKC). One such rare case of a PIOSCC, which presented as an OKC initially, is being reported.

Enriched vascularity in ameloblastomas, an indeterminate entity: Report of two cases.

Vascularity is a highly essential element that is required for the growth, development, and functioning of the body and variations in it can cause pathologies. It is one of the prime features of a proliferating lesion, where it aids in the growth of the lesion through its nutrition supply. Highly increased vascularity in a disease can itself affect the prognosis of the lesion, and in malignancies, it can induce tumor seeding and secondaries. Most of the pathologies including tumors, related to blood vessels, and vascularity are well established. There are some conditions, wherein altered vascularity is one of the prime components along with other diagnostic components of an established disease. In such cases, these lesions are diagnosed with special names, with varying biological behavior and prognosis in comparison to that of established entity. However, there still are few similar conditions whose nature is uncertain due to the rarity of the lesion and the insufficient scientific evidence which eludes the diagnostician. Here is the report of two cases of ameloblastoma, an established entity, with significant vascularity whose nature is indeterminate.