[Peculiarities of barbituric acid derivatives acute poisoning clinical picture in patients of elderly and senile age and their therapy.]

In this article materials obtained during treatment of 61 patients with acute poisoning with phenobarbital, which is part of Corvalol and Valocordin, are presented. It has already been established that phenobarbital acute poisoning in elderly and senile patients is accompanied by more frequent development of central nervous system, respiratory system (pneumonia) and cardiovascular system complications, which cause more severe clinical course and risk of an adverse outcome of acute poisoning. This research has shown that for hypoxia correction during phenobarbital acute poisoning in elderly and senile patients it is advisable to include Reamberin in the treatment regimen, which has no adverse effects on central haemodynamic parameters and effectively reduces severity of metabolic disorders.

[Using cytoflavin for prophylaxis and treatment of cognitive amnestic disorders in patients with heavy toxicohypoxic damage of brain].

Results of the therapy of patients with toxicohypoxic encephalopathy diagnosis upon heavy poisoning by psychotropic substances are presented. It is established that administration of the antihypoxant cytoflavin provides for a substantial decrease in the extent of metabolic disorders related to the development of heavy hypoxia. The use of cytoflavin significantly decreases the degree of encephalopathy and favors faster and better recovery of the mnestic and other cognitive functions in patients upon heavy toxicohypoxic brain damage caused by acute poisoning.

[Neuroprotective effects of succinate-containing antihypoxante reamberine in treatment of patients with toxicohypoxic brain injury].

As a result of survey in process of treatment of 60 patients with severe acute poisoning complicated by the toxic-hypoxic brain edema, found that inclusion of reamberin (antihypoxant containing succinate) in basic therapy leads to increase levels of the antioxidant defense system, decrease lipid peroxidation and reduce NR2A titers of autoantibodies. Reduction of degree of toxic-hypoxic encephalopathy promotes improving the clinical course, manifested shortened duration of coma and hospital bad days.

[Correction of tissue hypoxia with reamberin in severe forms of acute intoxication with neurotropic poisons].

Examination and treatment of 66 patients severely intoxicated with neurotropic poisons showed that inclusion of reamberin in combined therapy decreased the degree of tissue hypoxia as apparent from increased oxygen consumption, oxygen utilization index, and arteriovenous oxygen difference. This in turn accelerated recovery of antioxidant protection and lowered activity of lipid peroxidation. The use of reamberin for the treatment of acute neurotropic intoxication improves clinical conditions of the patients by decreasing duration of the comatose state, requirement for intensive therapy, and lethality.

[An experimental model of benzodiazepine intoxication]. / Eksperimental'naia model' otravleniia benzodiazepinami.

It has been demonstrated in rat experiments that intraperitoneal injection of 100 mg/kg phenazepam immobilizes the animals for one hour, causes long-term diminution of the muscular tonus and disturbed coordination of movements, tachycardia, hypotension, hyperthermia, depression of orientation and exploration motor activity, and disturbance of conditioned reflexes of active and passive avoidance. It is concluded that the changes in the above-indicated parameters of autonomic and behavioral status of rats under the effect of a 100 mg/kg dose of phenazepam are clearly expressed for a long period of time, are specific to the effect of benzodiazepines and may therefore serve as a model of severe BD intoxication for evaluating the efficacy of their antidotes. This has been confirmed in experiments with the well-known BD antagonist phlumazelin.

[Changes in the lesser circulation as affected by armin]. / Izmenenie krovoobrashcheniia v malom kruge pod vliianiem armina.

Experiments on narcotized cats have shown that intravenous administration of armine in DL50 (0.2 mg/kg) decreases the pulmonary blood flow by 52%. The reduction of the pulmonary blood flow is accompanied by a drop of pressure in the femoral artery, development of bronchoconstriction, bradycardia and arterial hypoxemia. The pressure in the lung artery remains rather high. At the beginning of intoxication the decrease of the pulmonary blood flow correlates with bronchoconstriction in a greater degree than with other indicators and as the pathological process deepens, the reduction of the pulmonary blood flow gets closely connected with bradycardia.