1.
Org Lett
; 2(18): 2877-80, 2000 Sep 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10964388
RESUMO
[reaction: see text] The reaction of imidazo[2,1-b]thiazolines with various organometallic reagents is described. Nucleophilic attack of organolithium reagents on sulfur occurs with extrusion of ethylene to produce 2-thioalkyl- or 2-thioarylimidazoles. The outcome with Grignard reagents, however, is less predictable, with some reagents adding at sulfur and others reacting at C-2 or not at all.