RESUMO
Features of free radical processes and their impact on the implementation of immunocompetent cells of their functions under conditions of peptic ulcer are insufficiently studied today. Reduced activity of catalase 1.7 and 3.4 times and that of glutathione peroxidise ~ 2.0 times, accordingly, were observed in both models of gastric ulceration (stress ulcer and ethanol one). Enzymatic activity of superoxide dismutase decreased 1.5 times and activity of glutathione transferase increased 1.8 times in the stress model in contrast to the ethanol model of stomach ulcer. Obtained results indicate the exhaustion of antioxidant system in rats' thymocytes under experi- mental ulcerogenesis. These data confirm complex negative effect of ulcer on the organism.
Assuntos
Antioxidantes/metabolismo , Úlcera Gástrica/enzimologia , Estresse Psicológico/complicações , Timócitos/enzimologia , Adaptação Fisiológica , Animais , Catalase/metabolismo , Modelos Animais de Doenças , Feminino , Glutationa Peroxidase/metabolismo , Glutationa Transferase/metabolismo , Masculino , Ratos , Restrição Física , Úlcera Gástrica/etiologia , Superóxido Dismutase/metabolismoRESUMO
Effects of natural antioxidants on the contents of lipids, proteins and carbohydrates in rat's gastric mucosal cells under experimental ethanolinduced ulceration have been studied. A significant decrease in the contents of neutral and phospholipids was found under experimental ulceration and their increase was detected under addition of squalene and ammivit. Under ulceration we found a significant decrease of protein fractions with molecular weight within the range of 11-138 kDa, galactose and fucose contents. Following addition of squalene and ammivit, a normalization of these parameters was observed.
