RESUMO
Preclinical safety of reamberin, a preparation of succinic acid intended for the treatment of patients with shock conditions of different etiology, and remaxol a drug intended for the treatment of patients with liver dysfunction caused by acute intoxication was performed. Both medicines belong to the 5th class of practically non-toxic drugs. Their administration to experimental animals for 30 days did not cause toxic effects on the functional and morphological state of main systems and organs. Both medicines do not affect specific (humoral and cellular) and non-specific immune response and do not cause sensibilization, mutagenic, embryotoxic and teratogenic effects, and also do no alter parameters of reproductive functions of rats.
Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Meglumina/análogos & derivados , Succinatos/efeitos adversos , Succinatos/farmacologia , Animais , Cães , Avaliação Pré-Clínica de Medicamentos , Feminino , Masculino , Meglumina/efeitos adversos , Meglumina/farmacologia , Ratos , Choque/tratamento farmacológicoRESUMO
Positive effects of angiogen, a preparation containing succinic and acetylsalicylic acids, on ECG, blood clotting, and lipid metabolism were demonstrated on animals with experimental cardiovascular disease induced by repeated injections of norepinephrine.
Assuntos
Aspirina/farmacologia , Pressão Sanguínea/efeitos dos fármacos , Fármacos Cardiovasculares/farmacologia , Doenças Cardiovasculares/tratamento farmacológico , Hemostasia/efeitos dos fármacos , Ácido Succínico/farmacologia , Animais , Coagulação Sanguínea/efeitos dos fármacos , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/induzido quimicamente , Doenças Cardiovasculares/fisiopatologia , Colesterol/sangue , Combinação de Medicamentos , Lipídeos/sangue , Masculino , Inibidores da Agregação Plaquetária/farmacologia , RatosAssuntos
Antiarrítmicos/farmacologia , Arginina Vasopressina/farmacologia , Arritmias Cardíacas/prevenção & controle , Aconitina , Anfetamina , Animais , Arritmias Cardíacas/induzido quimicamente , Arritmias Cardíacas/fisiopatologia , Atropina , Ketamina , Camundongos , Cloreto de Potássio , Ratos , TropanosRESUMO
It has been demonstrated in rat experiments that intraperitoneal injection of 100 mg/kg phenazepam immobilizes the animals for one hour, causes long-term diminution of the muscular tonus and disturbed coordination of movements, tachycardia, hypotension, hyperthermia, depression of orientation and exploration motor activity, and disturbance of conditioned reflexes of active and passive avoidance. It is concluded that the changes in the above-indicated parameters of autonomic and behavioral status of rats under the effect of a 100 mg/kg dose of phenazepam are clearly expressed for a long period of time, are specific to the effect of benzodiazepines and may therefore serve as a model of severe BD intoxication for evaluating the efficacy of their antidotes. This has been confirmed in experiments with the well-known BD antagonist phlumazelin.
