Assuntos
Oxigenoterapia Hiperbárica/efeitos adversos , Neoplasias Pulmonares/secundário , Animais , Contagem de Células , Feminino , Pulmão/patologia , Neoplasias Pulmonares/patologia , Masculino , Neoplasias Mamárias Experimentais/terapia , Camundongos , Camundongos Endogâmicos C3H , Transplante de Neoplasias , Transplante IsogênicoAssuntos
Adenocarcinoma/terapia , Oxigenoterapia Hiperbárica , Neoplasias Mamárias Experimentais/terapia , Metotrexato/uso terapêutico , Adenocarcinoma/radioterapia , Animais , Feminino , Neoplasias Mamárias Experimentais/radioterapia , Metotrexato/farmacologia , Camundongos , Camundongos Endogâmicos , Pele/efeitos dos fármacos , Pele/efeitos da radiação , Fatores de TempoRESUMO
The effect of methotrexate on solid rodent tumours has been investigated using the spontaneous mammary adenocarcinoma of the female C3H/Bts mouse. As these tumours exhibit a wide range of volume doubling times, calculations of tumour response to methotrexate must be related to doubling time. When methotrexate is injected into the tumour a dose-dependent tumour response is obtained. Systemic citrovorum "rescue" prevents methotrexate lethalities but reduces tumour response by a factor of 2. Methotrexate-treated tumours have an increased volume doubling time post treatment.
Assuntos
Adenocarcinoma/tratamento farmacológico , Neoplasias Mamárias Experimentais/tratamento farmacológico , Metotrexato/uso terapêutico , Adenocarcinoma/patologia , Animais , Relação Dose-Resposta a Droga , Feminino , Dose Letal Mediana , Leucovorina/farmacologia , Neoplasias Mamárias Experimentais/patologia , Metotrexato/administração & dosagem , Metotrexato/toxicidade , Camundongos , Camundongos Endogâmicos C3H , Fatores de TempoRESUMO
The effect of 70 MeV pi mesons was studied to determine the effectivness of such beams aginst normal tissues in vivo. The end points included thymic weight loss, oocyte and bone marrow CFU-S survival and the induction of macroscopid lens opacities. The results indicate that pi mesons are not signifacantly more effective for these end-points than more conventional radiation sources such as 60Co gama rays, 220 kVp X rays, and 14 MeV X rays and electrons. Nor was there any detectable difference in RBE between the peak and plateau regions of the pi meson beam. The significance of these findings is discussed in relation of the the published pi meson RBE values of between 1 therefore 4 and 5 therefore 0.
Assuntos
Partículas Elementares , Efeitos da Radiação , Animais , Medula Óssea/efeitos da radiação , Células da Medula Óssea , Catarata/etiologia , Relação Dose-Resposta à Radiação , Feminino , Cristalino/efeitos da radiação , Masculino , Camundongos , Tamanho do Órgão/efeitos da radiação , Ovário/efeitos da radiação , Timo/efeitos da radiação , Fatores de TempoRESUMO
Litters of 8- to 10-day-old nestling rats were protected against whole-body x-irradiation by cysteamine, AET, and deep hypothermia, singly, and by a combination of cysteamine pretreatment and deep hypothermia. The different treatments were randomized among littermates to minimize animal variation. A comparison of the LD50(30) values obtained for the different treatments gave a dose-reduction factor of 3.3 for the combined treatment, which was significantly greater than the factor for hypothermia alone, 2.6, or that for cysteamine alone, 1.4. Cysteamine therefore provided additional protection in the fully hypoxic (hypothermic) animal. Judged from the histological appearance of the gonads of the surviving male nestling rats, killed 30 days after irradiation, hypothermia afforded some protection to the germinal epithelium. Cysteamine, although injected when the testes were abdominal, had no demonstrable protective effect.
