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Ecotoxicol Environ Saf ; 269: 115745, 2024 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-38029583

RESUMO

Magnetic graphene oxide nanocomposites (MGO NPs) have been widely studied in biomedical applications. However, their cytotoxicity and underlying mechanisms remain unclear. In this study, the biosafety of MGO NPs was investigated, and the mechanism involved in ferroptosis was further explored. MGO can produce cytotoxicity in ADSCs, which is dependent on their concentration. Ferroptosis was involved in MGO NP-induced ADSC survival inhibition by increasing total ROS and lipid ROS accumulation as well as regulating the expression levels of ferroptosis-related genes and proteins. GPX4 played a critical role in the MGO NP-induced ADSC ferroptosis process, and overexpressing GPX4 suppressed ferroptosis to increase cell survival. This study provides a theoretical basis for the biosafety management of MGO NPs used in the field of biomedical treatment.


Assuntos
Ferroptose , Grafite , Nanocompostos , Fosfolipídeo Hidroperóxido Glutationa Peroxidase , Ferroptose/genética , Grafite/toxicidade , Óxido de Magnésio , Fenômenos Magnéticos , Nanocompostos/toxicidade , Espécies Reativas de Oxigênio , Animais , Ratos , Células-Tronco Mesenquimais/metabolismo , Fosfolipídeo Hidroperóxido Glutationa Peroxidase/metabolismo
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