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1.
PLoS One ; 10(8): e0136208, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26291982

RESUMO

The androgen receptor (AR) gene polymorphism in humans is linked to aggression and may also be linked to reproduction. Here we report associations between AR gene polymorphism and aggression and reproduction in two small-scale societies in northern Tanzania (Africa)--the Hadza (monogamous foragers) and the Datoga (polygynous pastoralists). We secured self-reports of aggression and assessed genetic polymorphism of the number of CAG repeats for the AR gene for 210 Hadza men and 229 Datoga men (aged 17-70 years). We conducted structural equation modeling to identify links between AR gene polymorphism, aggression, and number of children born, and included age and ethnicity as covariates. Fewer AR CAG repeats predicted greater aggression, and Datoga men reported more aggression than did Hadza men. In addition, aggression mediated the identified negative relationship between CAG repeats and number of children born.


Assuntos
Agressão , Polimorfismo Genético , Receptores Androgênicos/genética , Reprodução , Adolescente , Adulto , Idoso , Criança , Família , Humanos , Masculino , Casamento , Pessoa de Meia-Idade , Tanzânia/etnologia , Repetições de Trinucleotídeos , Adulto Jovem
2.
Sci Rep ; 3: 3148, 2013 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-24193094

RESUMO

The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga. Buss and Perry's Aggression Questionnaire was used to measure aggression. The number of CAG repeats in the AR gene was negatively correlated with physical aggression, anger, and hostility. Among the genes of the dopaminergic system, a significant single-gene effect was detected only for DRD2 with regard to anger. At the level of a two-gene model, a significant effect for DRD2 and a tendency for DAT1 were observed for the DAT1-DRD2 gene pair regarding hostility, and two tendencies were observed for the interaction effect of the DAT1-COMT pair regarding anger and hostility. These data suggest a probable link between physical aggression and direct fitness caused by strong sexual selection in Datoga men.


Assuntos
Agressão/fisiologia , Catecol O-Metiltransferase/genética , Proteínas da Membrana Plasmática de Transporte de Dopamina/genética , Polimorfismo Genético , Receptores Androgênicos/genética , Receptores de Dopamina D2/genética , Adolescente , Adulto , Idoso , Ira/fisiologia , Genótipo , Hostilidade , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Tanzânia , Repetições de Trinucleotídeos , Adulto Jovem
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