1.
Bioorg Med Chem Lett
; 13(5): 809-12, 2003 Mar 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12617896
RESUMO
19-norvitamin D A-ring phosphine oxide 5 was synthesized by a new sequence mode starting from D-glucose as a chiral template. Transformation of the pyranoside ring into the A-ring carbocycle was achieved by the Pd-catalyzed Ferrier rearrangement. The phosphine oxide 5 was obtained in an 18% overall yield by this novel cost-effective method.