1.
Nat Struct Mol Biol
; 19(7): 719-21, 2012 Jun 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22705790
RESUMO
We present the first large-scale identification of lariats-the transient branched introns that are released as a byproduct of pre-mRNA splicing. The locations of the branchpoints in these introns provide insight into the early steps of splicing. From this data set, we have developed a comprehensive model of 3' splice-site selection, identified new mechanisms of alternative splicing and mapped the distribution of splicing factors around branchpoints.