Comparison of serum alkaline phosphatase levels between two measurement methods in chronic hemodialysis patients in Japan: involvement of ABO blood group system and relationship with mortality risk.

BACKGROUND: Elevated serum alkaline phosphatase (ALP) levels are a risk factor for all-cause mortality in hemodialysis patients. Traditionally in Japan, ALP measurements were conducted using the JSCC method, which yields higher ALP measurement values than the IFCC method, mainly due to its increased sensitivity to intestinal ALP. METHODS: Serum total ALP levels before and after switching the assay method from JSCC to IFCC were compared among different blood types in 521 hemodialysis patients (Study 1). The association between ALP levels measured by the JSCC method and 7-year mortality was analyzed, including blood types and liver function parameters as covariates, in 510 hemodialysis patients (Study 2). RESULTS: ALP levels measured by the JSCC method were approximately three times higher than those measured by the IFCC method, with significant elevation in patients with blood types B and O compared to those with blood types A and AB. Similarly, ALP levels measured by the IFCC method were significantly higher in patients with blood types B and O compared to those with blood types A and AB (Study 1). The highest tertile of ALP levels showed a significantly increased risk of all-cause mortality, even after adjusting for patient background. However, this significance disappeared when serum liver function-related or inflammatory markers were included as covariates (Study 2). CONCLUSION: ALP levels measured by the JSCC method are associated with life prognosis, but caution should be exercised due to their elevation in patients with blood types B and O and in those with hepatic dysfunction or inflammation.

An Elderly Patient Developed Ulcerative Colitis after SARS-CoV-2 mRNA Vaccination: A Case Report and Review of the Literature.

An 86-year-old man presented to our hospital with symptoms of diarrhea and bloody stool, which had manifested two weeks after receiving his third severe acute respiratory syndrome coronavirus 2 mRNA vaccination. Colonoscopy revealed diffuse, rough-surfaced mucosa extending from the ascending colon to the rectum. Despite attempting probiotic treatment, the patient's condition did not improve, leading to admission. Endoscopic findings at admission worsened. Based on endoscopic and histopathological findings, the patient was diagnosed with ulcerative colitis. Corticosteroids and 5-aminosalicylic acid were administered, and the clinical symptoms improved. Subsequently, the disease worsened during steroid tapering, and filgotinib was added, leading to steroid-free remission.

Changes in Collective Efficacy's Preventive Effect on Intimate Partner Violence during the COVID-19 Pandemic.

Following the logic of studies showing that collective efficacy within neighborhoods deters intimate partner violence (IPV), the promotion of social distancing during the COVID-19 pandemic may have weakened that effect. To examine that possibility, we analyzed panel data from 318 adults in Japan regarding IPV victimization and perceived collective efficacy at four time points. A latent growth model (LGM) analysis for each measure revealed that informal social control, a subscale of collective efficacy, has declined since the pandemic began, whereas no significant changes have occurred in social cohesion and trust, another subscale of collective efficacy, and IPV victimization. Furthermore, two parallel LGM analyses revealed that although collective efficacy before the pandemic suppressed subsequent IPV victimization, changes in collective efficacy during the pandemic have been positively associated with changes in IPV. Those results suggest that collective efficacy's protective effect on IPV is moderated by whether interactions between intimate partners and their neighbors are socially normative.

A Spatial Regression Analysis on the Effect of Neighborhood-Level Trust on Cooperative Behaviors: Comparison With a Multilevel Regression Analysis.

There is no reason to suppose that neighborhood effects based on residents' trust vary according to administrative boundaries. We examined the relationship between neighborhood trust and cooperative behaviors using the spatial Durbin model which assumed that people are influenced by closer neighbors regardless of administrative boundaries, comparing the results with those of the multilevel model. We used data from 476 residents in Arakawa Ward, Tokyo, Japan. For each respondent, we assigned a unique 'neighborhood trust' value weighted by the inverse distance between the respondent and all other respondents as an independent variable. The dependent variables were perceived neighbors' cooperative behaviors and respondents' own cooperative behaviors. The spatial Durbin model showed that spatially weighted neighborhood trust was positively associated with cooperative behaviors. Meanwhile, the multilevel models did not show the statistically significant effect of neighborhood trust. We concluded that the spatial model might model the neighborhood effects in society more precisely.

[The effects of crime information and response effectiveness on behavioral intentions of coping with crime].

A survey and an experiment were conducted about the promotion of behavioral intentions for preventing sexual assaults by strangers. The study focused on the "identifiable victim effect", where contextual descriptions of a single victim resulted in the collection of more donations than statistical descriptions of victims. A survey of 42 police websites that made recommendation for preventing sexual assaults revealed that only 3.3% of the threat messages described identifiable victims, whereas 50.0% referred to statistical figures. Additionally, only 9.5% of the coping recommendations mentioned the effectiveness of the recommendation. In the experiment, 207 female university students were randomly presented with one of four threat messages featuring victims (statistical, identifiable, combination, or none), followed by recommendation of high-efficacy or low-efficacy response. ANOVA indicated interaction effects of threat type and response efficacy on behavioral intentions. The effect of threat messages was statistically significant only when a high-efficacy response was recommended. The difference in behavioral intentions for different types of threats partly replicated the findings in donation. These results suggest that current threat appeals for crime prevention need refinements regarding both the threat description and response the efficacy.