1.
Org Biomol Chem
; 18(38): 7545-7548, 2020 10 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32959040
RESUMO
Lewis acid-assisted palladium-catalysed dealkoxylation of N-alkoxyamides has been developed. This reaction proceeded smoothly with a range of N-alkoxyamides in the absence of an external reductant, thereby establishing a convenient and reductant-free protocol. In addition, a gram-scale reaction could be achieved. Preliminary mechanistic investigations indicated that ß-hydrogen elimination from a palladium alkoxide intermediate generated an intramolecular hydride source.