[The outcome and course of IHD in patients with normal and altered coronary arteries under 10-15 years of observation]. / Iskhod i techenie IBS u bol'nykh s normal'nymi i izmenennymi koronarnymi arteriiami pri 10-15-letnem nabliudenii.

The course and prognosis of ischemic heart disease (IHD) were studied in 175 anginal IHD patients regularly examined coronarographically for 10-15 years. The clinical, bicycle ergometry and coronarography findings have given evidence for design of prognostic risk criteria. The first 3 years of the follow-up have shown cases of lethal and transmural myocardial infarction to occur only in high-risk group. Low-risk patients developed transmural myocardial infarction on follow-up year 7, while lethal outcome occurred 14 years after the start of the observation. In patients with normal or insignificantly changed coronary arteries the above events were not observed.

[Clinical and functional characteristics of patients with ischemic heart disease in long-term remission of angina pectoris]. / Kliniko-funktsional'naia kharakteristika bol'nykh ishemicheskoi bolezn'iu serdtsa s dlitel'noi remissiei stenokardii.

Long-term (5-15-year) prospective surveys of 171 angina patients have yielded clinical, coronarographic, and bicycle ergometric criteria for predicting the favourable course of the disease. A prolonged (at least 3 years) clinical anginal remission was observed in 43 (25.1%) patients. The patients had typical features: a short (less than 6-9 months) history of classical angina, the age at the onset of CHD under 50 years; high performance during bicycle ergometric test, lack of angina after sustained so-called "accomplished" myocardial infarction. The coronarograms of patients with a long-term anginal remission most frequently displayed severe stenosis or occlusion of "unsafe" site of a large coronary artery. The duration of remission was less than 10 years if atherosclerosis also affected the remaining coronary arteries. That of remission was more than 10-15 years, if the remaining coronary arteries proved completely intact.

The use of lipid indicators and indexes for assessment of ischaemic heart disease.

The informative value of various lipid indicators and indexes in healthy subjects and in patients with ischaemic heart disease (IHD) is compared. In 10 investigated biochemical indicators significant differences were found between healthy people and subjects with epidemiological or clinical signs of IHD. The first places in the order according to Anderson-Bahadur intervals were held by the cholesterol atherogenity index, total cholesterol (CS) and the percent of high-density lipoproteins cholesterol (HDL-CS) in total CS. The cholesterol atherogenity index and HDL-CS percent in total CS were closely correlated with the severity of angiographically proved changes in the coronary arteries.

[Data on repeated studies on the blood lipid levels in evaluating the severity of chronic ischemic heart disease]. / Dannye povtornykh issledovanii sederzhaniia lipidov v krovi v otsenke tiazhesti khronicheskoi ishemicheskoi bolezni serdtsa.

During 3 years cholesterol, triglyceride and lipoprotein levels were repeatedly determined in the blood of 125 patients with coronary disease, and the severity of the disease was assessed with bicycle ergometry and coronarography. A relationship has been established between the severity of the disease and its course and the degree of disorders in the lipid metabolism. Group with stable normolipidemia (28%) showed less manifest symptoms of the disease and absence of rapid progression with new coronary accidents. Groups with hyperlipoproteinemia both stable (52.8%) and transient (19.2%) had predominantly severe forms of the disease running unfavourable course. The more frequent with severe and extended, according to angiography atherosclerosis of the coronaries and unfavourable course of disease were associated with hyperlipoproteinemia type II.

[Rifampicin in the therapy of gonorrheal urethritis in men]. / Rifampitsin v terapii gonoreinykh uretritov u muzhchin

The therapeutic efficiency of benemycin (rifampicin of Polish production), a semisynthetic antibiotic was studied in 96 male cases with gonorrhea urethritis. The antibiotic was used in a dose of 300 mg every 6 hours (2.1--3gm for the treatment course depending on the desease severity). Observation of the patients for 1--2 months showed etiological recovery in 91 (94.8 per cent) out of 96 patients. Postgonorrhea inflammatory processes were observed in 8.7 per cent of the cases. For studying late results of the treatmant 62 patients were observed for 3 to 12 months. Gonococci were isolated from none of the patients. No side reactions were found in the patients treated with rifampicin.