[Intraindividual variation in hematological parameters]. / Intraindividualna variatsiia na khematologichni parametri.

The hematological indices--erythrocytes, hemoglobin, hematocrit, mean volume of erythrocytes and leukocytes were studied in a group of 14 clinically healthy volunteers, medical workers, weekly in the course of three successive months via an automatic hematological analyser PHA 1/2 for the determination the quantity of the intraindividual variation. No significant discrepancy was established, via F-test in the quantities of the standard deviation in the males and females studied, providing grounds for the authors to calculate the mean quantities of the intraindividual variation of the mentioned parameters for clinically healthy subjects.

[Results of the short-term (28 days) cimetidine treatment of duodenal ulcer]. / Rezultati ot kratkotraino (28 dni) lechenie sus simetidin na bolni s iazva na dvanadesetoprustnika.

The results from a short-term (28 days) treatment of patients with duodenal ulcer are reported. The average surface of the ulcers from 40.4 mm2 (initial average value) diminished to 7.3 mm2 by the 14 th day of the treatment. The graphic study of the kinetics of healing of the ulcer process revealed that in a treatment with 0.8--1.0 g Simetidin, a diminution of the ulcer by half (t/2) could be expected by the seventh day. In 16, out of the 21 treated, the ulcer epithelized by the 14th day of the treatment. In one patient a prolonged treatment of 42 days proved to be necessary to guarantee the epithelization of the ulcer. In 2/3 of treated patients, the pain complaints, the sensation of warmth and acidity disappeared by the end of the first week of the treatment. The average values of the basic and peak acid output (BAO and PAO), the N-acetyl neuramine acid output, the gastrin basic level, GOT, GPT and creatinine in serum do not change after the treatment. A significant reduction of hemoglobin concentration in the gastric juice is established after the treatment with Simetidin.