[Balance of steroid hormones among children and teenagers with epilepsies].

The level of steroid hormones (cortisol, cortisone, aldosterone) in children with epilepsy, aged from 4 to 18 years, was investigated. The levels of cortisol, cortisone and aldosterone were changed in 58.0%, 32.0% and 62.0% of patients with pharmacoresistant epilepsy, respectively, compared to age-matched controls. In case of epilepsy with positive effect of antiepileptic treatment, the changes of aldosterone were found only in 40.6% of patients. The level of hormones was, to a certain extent, age-dependent only in pharmacoresistant epilepsy. The greatest changes are registered in the following periods: at the age 4-7 years, the cortisone level corresponded to the norm in 33.3%, aldosterone in 44.4%; at the age 12-16 years, the indexes of cortisol corresponded to the norm in 26.7%, aldosterone in 20.0%; at the age 8 − 11 years, only the level of aldosterone was changed, it corresponded to the norm in 35.3% of cases.

[Leukocytosis and outcomes of acute stroke].

We carried out the retrospective analysis of 300 disease histories of patients with stroke hospitalized in the first 24 h of the disease. The presence of leukocytosis and its severity were evaluated as predictors of outcome. The level of leukocyte-erythrocyte aggregations in the blood film was determined in some patients. The analysis revealed that the higher was leukocytosis, the more severe was the course of stroke and the higher was frequency of fatal outcomes. Patients with stroke more often had neutrophilic leukocytosis than monocytosis, the former was the predictor of worse prognosis. The most unfavorable prognosis was observed in patients with hemorrhagic stroke and leukocytosis. The higher was the number of leukocytes, the higher was the probability of fatal outcome in the first month of stroke. The level of leukocyte-erythrocyte aggregations dramatically increased in the blood of stroke patients that promoted the disturbance of microcirculation and worsened significantly the disease prognosis.

[Stroke epidemiology and evaluation of risk factors significance for survival of patients during 28 poststroke days in the open population of Chita]. / Epidemiologiia insul'ta i otsenka znachimosti faktorov riska v vyzhivaemosti bol'nykh v pervye 28 dnei zabolevaniia v otkrytoi populiatsii Chity.

To provide effective primary and secondary stroke prevention, the epidemiological stroke rates were investigated in the open population of a large Transbaykal town by the register method. During one year, 989 cases have been examined in the population aged above 25 years. The age-standardized stroke incidence rate (per 100 000 persons) was 300 in women and 329 in men. The age-standardized stroke morbidity (per 100 000 persons) was 390 in women and 409 in men. Stroke mortality was 77 in women and 81 in men per 100 000 (p = 0.01). The stroke mortality in men was higher than in women. Stroke case fatality was 20% in men and 16% in women. The prevalence and significance of the main cardiovascular risk factors were revealed among patients by case-control study. Hypertension, psychological and social risk factors were the most significant in Chita's population of stroke patients.