1.
Nucl Med Rev Cent East Eur
; 13(2): 49-54, 2010.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21598226
RESUMO
The ¹77Lu-[tris(1,10-phenanthroline)lutetium(III)] complex (¹77Lu-PQ3) was prepared successfully with high radiochemical purity (> 99%). Lu-177 chloride was obtained by thermal neutron flux (4 × 10¹³ n.cm⻲.s⻹) of natural Lu2(NO3)3 sample, dissolved in acidic media. The radiochemical yield was checked by measuring the radiochemical purity of the (177)Lu-PQ complex by ITLC (10 mM DTPA, pH = 5, as mobile phase). The final complex solution was injected intravenously into wild-type male rats and bio-distribution of the complex was checked for up to 48 hours. The dose limiting organs were shown to be the reticulu-endothelial system. The bio-distribution of the labelled compounds in tumour-bearing animals is under investigation.