RESUMO
We prospectively analyzed the coagulation abnormalities in 111 children with Celiac disease at diagnosis and its association with histology grade on duodenal biopsy; 27% had deranged prothrombin time. There was an increasing proportion of coagulopathy with progression of Marsh Grade on duodenal histology.
Assuntos
Transtornos da Coagulação Sanguínea , Doença Celíaca/complicações , Doença Celíaca/epidemiologia , Adolescente , Transtornos da Coagulação Sanguínea/complicações , Transtornos da Coagulação Sanguínea/diagnóstico , Transtornos da Coagulação Sanguínea/epidemiologia , Criança , Pré-Escolar , Feminino , Humanos , Índia/epidemiologia , Lactente , Coeficiente Internacional Normatizado , Masculino , Estudos ProspectivosAssuntos
Anemia , Doença Celíaca , Dieta Livre de Glúten/métodos , Duodeno/patologia , Anemia/diagnóstico , Anemia/epidemiologia , Anemia/etiologia , Biópsia , Estatura , Doença Celíaca/complicações , Doença Celíaca/diagnóstico , Doença Celíaca/dietoterapia , Doença Celíaca/epidemiologia , Doença Celíaca/fisiopatologia , Criança , Diagnóstico Precoce , Endoscopia Gastrointestinal/métodos , Endoscopia Gastrointestinal/estatística & dados numéricos , Feminino , Proteínas de Ligação ao GTP/análise , Humanos , Índia/epidemiologia , Masculino , Prevalência , Proteína 2 Glutamina gama-Glutamiltransferase , Estudos Retrospectivos , Transglutaminases/análiseAssuntos
Meningites Bacterianas/diagnóstico , Meningites Bacterianas/microbiologia , Infecções Estafilocócicas/diagnóstico , Infecções Estafilocócicas/microbiologia , Staphylococcus , Fatores Etários , Antibacterianos/uso terapêutico , Criança , Feminino , Humanos , Meningites Bacterianas/tratamento farmacológico , Infecções Estafilocócicas/tratamento farmacológico , Resultado do TratamentoRESUMO
Celiac disease is associated with several genetic disorders, but its association with hereditary fructose intolerance is rare. Hereditary fructose intolerance is a rare autosomal recessive disease of fructose metabolism presenting as vomiting after intake of fructose. An association between these two distinct genetic gastrointestinal disorders is important as treatment failure of celiac disease calls for careful evaluation for hereditary fructose intolerance. We report a patient with an association of these two disorders.
Assuntos
Doença Celíaca/dietoterapia , Intolerância à Frutose/dietoterapia , Doença Celíaca/complicações , Dieta Livre de Glúten , Intolerância à Frutose/complicações , Intolerância à Frutose/genética , Humanos , Lactente , MasculinoRESUMO
OBJECTIVE: To study the clinico-epidemiological profile of children hospitalized with dengue illness. METHODS: Prospective study of children hospitalized with the diagnosis of dengue illness during from September through November 2006 at a tertiary care centre in Jaipur. RESULTS: A total of 948 children including 671 (70.8%) boys and 277 (29.2%) girls were diagnosed to have dengue illness during the outbreak. Two third of children were from urban areas while 6-12 years was the most commonly affected age group (45.8%). 58.3% cases had dengue fever (DF) while 41.7% had DHF (dengue hemorrhagic fever). Dengue fever with bleed (DFB) accounted for 32% of cases. Common constitutional symptoms were vomiting (35.2%), pain abdomen (22.1%) and myalgia (10.1%). Bleeding manifestations were observed in 44.5% of cases.. Positive tourniquet test was the most common manifestation which was seen in 300 cases (31.6%) while in 9.2% cases bleeding was the only manifestation. Epistaxis (25%) was the most common spontaneous bleeding manifestation. Thrombocytopenia was documented in 84% of total cases and bleeding occurred more often in patients with severe thrombocytopenia. Ten children expired with a case fatality rate of 1.1%. CONCLUSIONS: Children between 6 and 12 yrs were most affected by dengue with larger number of cases from urban areas. DFB cases accounted for almost one third cases of dengue. Epistaxis was the most common spontaneous bleeding manifestation. Bleeding occurs more often in patients with severe thrombocytopenia.
