RESUMO
The effect of external magnetic field (direct and alternating) on the targeted delivery and distribution in body tissues of experimental animals of anesthetics (novocain, lidocaine, and trimecaine) immobilized on highly dispersed ferromagnetics with biocompatible coating was studied by the method of emission spectral analysis. The results are compared with the results obtained earlier on highly dispersed iron powders with dextran coating. The parameters for the powders with dextran coating are considerably lower than those for the magnetic carriers with the polyacrylamide coating.
Assuntos
Resinas Acrílicas , Anestésicos/farmacocinética , Sistemas de Liberação de Medicamentos , Ferro , Magnetismo , Anestésicos/administração & dosagem , Animais , Portadores de Fármacos , Lidocaína/administração & dosagem , Lidocaína/farmacocinética , Microesferas , Tamanho da Partícula , Pós , Procaína/administração & dosagem , Procaína/farmacocinética , Coelhos , Distribuição Tecidual , Trimecaína/administração & dosagem , Trimecaína/farmacocinéticaRESUMO
Directed delivery and distribution of anaesthetics (novocaine, lidocaine, trimecaine) immobilized on finely dispersed iron powders under the influence of an external magnetic field in body tissues of test animals have been studied. The data of emission spectral analysis relating to concentration of iron in soft and bone tissues of animals influenced by constant and alternating magnetic field on front and reverse sides over a period from 0 to 180 min are given.
Assuntos
Anestésicos Locais/administração & dosagem , Anestésicos Locais/farmacocinética , Sistemas de Liberação de Medicamentos , Ferro/administração & dosagem , Ferro/farmacocinética , Animais , Portadores de Fármacos , Campos Eletromagnéticos , Cobaias , Lidocaína/administração & dosagem , Lidocaína/farmacocinética , Camundongos , Procaína/administração & dosagem , Procaína/farmacocinética , Trimecaína/administração & dosagem , Trimecaína/farmacocinéticaRESUMO
Studies of the mechanical properties and electron microscopic examination of 12X18H9T steel surface in dentures have revealed their changes after mechanical load. Complex corrosive destruction of dentures in the oral cavity is regarded as stress corrosion.