[Morphological and immunological comparisons in epilepsy]. / Morfologicheskie i immunologicheskie sopostavleniia pri épilepsii.

Morphological and immunological assays were employed to examine 18 epileptic patients and 40 Krushinskii-Molodkina rats undergoing subconvulsive and convulsive acoustic stimulations. After multiple audiogenic epileptiform convulsive fits the epileptogenic areas of the brain of epileptic patients (biopsy material) and the neocortex of the sensorimotor area, amygdaloid complex and hippocampus of rats manifested vascular alterations in the form of chronic or subacute vasculitis. The changes revealed in the ratio of B and T lymphocytes in the peripheral blood of the epileptic patients in combination with pronounced stimulation of cellular and humoral immunity responses to antigens of homologous and autologous brain extracts, more well-defined in marked inflammatory process, may attest to the immune genesis of endo- and perivasculitis.

[Clinico-immunologic correlations in epilepsy]. / Kliniko-immunologicheskie korreliatsii pri épilepsii.

In 51 epileptic patients with frequent attacks, the clinical manifestations were correlated with some parameters of immune responsiveness. The authors determined the content of plasma globulins of the main classes, cerebral antibodies, T and B lymphocytes, the rate of the inhibition of the leukocyte migration with respect to the cerebral antigen. Epilepsy was shown to run its course in the presence of immune responsiveness depression. A certain relationship existed between the duration of the disease, the endogenic factors, the nature of fits and some immunologic indices. With the development of the disease, the initial deficiency of the B lymphocyte immunity was coupled with the progressive dysfunction of the T lymphocyte immunity.

[Cerebrospinal fluid immunoglobulins in patients with acute tick-borne encephalitis]. / Immunoglobuliny spinnomozgovoi zhidkosti u bol'nykh ostrym kleshchevym éntsefalitom.

Data characterizing the quantitative parameters and the spectrum of basic non-specific and specific immunoglobulins (IgA, IgG, IgM) in the cerebrospinal fluid (CSF) of patients with acute tick-borne encephalitis are presented. Statistically significant differences in the intensity and character of the changes in the protein constituents of the CSF were revealed in patients with the subclinical form and forms accompanied with the brain affection. On the basis of evaluating the cerebral microcirculation in the patients with tick-borne encephalitis, and determining the correlation between the content of immunoglobulins in the CSF and the serum an idea is suggested that of a certain significance for the rise of the immunoglobulin levels is (in addition to their local synthesis in the CNS) the phenomenon of protein filtration through the damaged hematoencephalic barrier in the acute period of the infection.