[Clinico-morphological characteristics of cardiogenic non-bacterial cerebral embolism]. / Kliniko-morfologicheskie osobennosti kardiogennykh nebakterial'nykh émbolii sosudov golovnogo mozga.

Clinical and morphological studies were carried out in 194 patients who died in the acute period of ischemic brain stroke. Disorders of the heart rhythm were found to play the leading part in the origin of cardiogenic embolisms of cerebral vessels. It has been recorded that left atrial thrombus formation was prevalent in heart rhythm disorders whereas left ventricular was prevalent in lack of those disorders. In different heart diseases complicated by atrial fibrillation and cerebral thromboembolism, the one-third of cases did not show any heart thromboses. The content of embolisms in cerebral arteries corresponded to the material of their source, whereas the site was specified by mechanical obstruction, with no changes in the vascular wall. It has been disclosed that in the majority of cases, stable embolism precipitates white infarction or white infarction with the hemorrhagic component whereas embolus lysis is responsible for hemorrhagic infarction and (or) a transitory ischemic attack. The clinical manifestations of hemorrhagic infarction differ from white infarction in less gravity and regression of the neurological symptomatology.

[Experimental model of transient cerebral circulatory disorders by way of embolization of cerebral arteries with fresh blood clots]. / Eksperimental'naia model' prekhodiashchikh narushenii mozgovogo krovoobrashcheniia putem émbolizatsii mozgovykh arterii svezhimi sgustkami krovi

A total of 85 experimental animals received through the blood flux of the carotid arteries clots of autogenic blood of 1 hour age. A histomorphological study after 40 minutes following an embolism there were revealed clots in the cerebral arteries in 13 out of 14 animals. After 1.5 hours in 1 of 17, and after 24 hours in none of the 10 animals. Directly following the administration of clots in all the 20 animals of this series, there were symptoms of focal brain lesions: hemipareses, ptosis and myosis, a "trot around circles", etc. In all 20 animals there was a complete regress of the symptom at different times (from 10 min to 18 hours). In all cases there was an increased amount of lactic acid in the cerebral blood outflow while subsequently was reduced, correlating with the time of clot lysis. The morphological control did not depict brain infarctions. It is assumed that the reason of brain dysfunctions is an obturation by blood clots of cerebral arteries, while their normalization is due to a spontaneous lysis of the embols which obturated the cerebral arteries.