The effect of NSAID on T-cell ratios in marginal periodontitis.

The use of NSAID in the treatment of periodontal disease can augment the conventional periodontal therapy. NSAID can block prostaglandin synthesis which is responsible for the progression of periodontal disease. Inhibition of prostaglandin synthesis reduces the alveolar bone loss, loss of attachment, gingival inflammation and consequently pocket depth. Results of the present study show that the use of NSAID increases the T-cell ratios indicating an improvement of T-cell function which is represented clinically by the reduction in G.I scores.