1.
Org Lett
; 5(20): 3703-4, 2003 Oct 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14507209
RESUMO
[reaction: see text] The Heck reaction is a more efficient and reliable method than previous ones for introducing a C3 unit at the benzyl position for the synthesis of Beraprost. Especially, trialkylated long-chain amines such as (n-C(8)H(17))(3)N and (n-C(12)H(25))(3)N resulted in good yields. This development will be used for the industrial synthesis of Beraprost.