RESUMO
JGP study (Rayaprolu et al. https://doi.org/10.1085/jgp.202313467) shows that hydrophobic residues in the S1 transmembrane domain modulate the voltage sensor movements and enzymatic activity of voltage-sensing phosphatase.
Assuntos
Interações Hidrofóbicas e Hidrofílicas , Animais , HumanosRESUMO
JGP study (Duno-Miranda et al. https://doi.org/10.1085/jgp.202313522) shows that a mutation linked to dilated cardiomyopathy stabilizes ß-cardiac myosin in its autoinhibited, super-relaxed state.
Assuntos
Mutação , Humanos , Cardiomiopatia Dilatada/genética , Cardiomiopatia Dilatada/metabolismo , AnimaisRESUMO
JGP study (Asghari et al. 2024. J. Gen. Physiol.https://doi.org/10.1085/jgp.202213108) indicates that ß-adrenergic signaling enlarges dyads and reorganizes RyR2 tetramers in cardiomyocytes.
Assuntos
Miócitos Cardíacos , Canal de Liberação de Cálcio do Receptor de Rianodina , Fosforilação , Canal de Liberação de Cálcio do Receptor de Rianodina/química , Transdução de SinaisRESUMO
JGP study (Lucero et al. http://www.doi.org/10.1085/jgp.202313464) shows that members of the SMRGdx subtype can export the degradation products of metformin, helping bacteria adapt to high environmental levels of the commonly prescribed diabetes medication.
Assuntos
Proteínas de Membrana Transportadoras , MetforminaRESUMO
JGP study (Bernas et al. 2024. J. Gen. Physiol.https://doi.org/10.1085/jgp.202313436) suggests that, by altering microtubule dynamics, persistent PKA activation promotes the delivery of Nav1.5 channels to intercalated discs.
RESUMO
JGP study (this issue, Caremani et al. https://doi.org/10.1085/jgp.202313393) reveals that the calcium sensitivity of thick filament structure in skeletal muscle is greater than that of force, offering new insights into the mechanisms of thick filament activation.
Assuntos
Cálcio , Músculo Esquelético , SarcômerosRESUMO
JGP study (In this issue, Osten et al. https://doi.org/10.1085/jgp.202313377) suggests that, by altering mechanosensitive signaling pathways, replating stem cell-derived cardiomyocytes changes myosin expression and contractile function.
Assuntos
Contração Muscular , Miosinas , Transdução de SinaisRESUMO
JGP study (Komondor et al. 2023. J. Gen. Physiol. https://doi.org/10.1085/jgp.202213258) reveals that conventional PLC activation pathways are not required for the fertilization-induced depolarization of Xenopus eggs that prevents the entry of additional sperm.
Assuntos
Fertilização , Óvulo , Sêmen , Xenopus , Animais , Xenopus/fisiologia , Óvulo/fisiologiaRESUMO
JGP study (Hermanstyne et al. 2023. J. Gen. Physiol.https://doi.org/10.1085/jgp.202213310) shows that Kv12-encoded K+ currents reduce the repetitive firing rates of SCN neurons at night, thereby regulating daily oscillations in the master circadian pacemaker.
Assuntos
Ritmo Circadiano , Núcleo Supraquiasmático , Ritmo Circadiano/fisiologia , Núcleo Supraquiasmático/fisiologia , Neurônios/fisiologiaRESUMO
JGP study (Kopec et al. 2023. J. Gen. Physiol.https://doi.org/10.1085/jgp.202213166) reveals how interactions with pore-helix residues control filter inactivation in the prokaryotic potassium channel MthK.
RESUMO
JGP study (Lehman and Rynkiewicz. 2023. J. Gen. Physiol.https://doi.org/10.1085/jgp.202313387) suggests that tropomyosin regulates the crossbridge cycle in muscle by pivoting around relatively fixed points on actin thin filaments.
Assuntos
Actinas , Tropomiosina , Citoesqueleto de Actina , Músculos , CálcioRESUMO
JGP study (Gada et al. 2023. J. Gen. Physiol. https://doi.org/10.1085/jgp.202213255) reveals that the membrane lipid PI(4,5)P2 alters the activity of NaV1.4 channels by modulating their gating behavior.
Assuntos
Canais de Sódio Disparados por Voltagem , Lipídeos de MembranaRESUMO
JGP study (Takeuchi and Kurahashi. 2023. J. Gen. Physiol.https://doi.org/10.1085/jgp.202213165) reveals that segregation of signals within sensory cilia allows Ca2+ to play opposing roles in olfactory signal transduction.
Assuntos
Neurônios Receptores Olfatórios , Neurônios Receptores Olfatórios/fisiologia , Cílios , Cálcio , Transdução de Sinais/fisiologia , Olfato/fisiologiaRESUMO
A new gating current recording protocol shows that gating hysteresis is a kinetic phenomenon, rather than an inherent thermodynamic property of Shaker potassium channels.
Assuntos
Ativação do Canal Iônico , Canais de Potássio , Canais de Potássio/metabolismo , Superfamília Shaker de Canais de Potássio , Cinética , Termodinâmica , Oócitos/metabolismoRESUMO
JGP study reveals how the neurotransmitter PACAP induces a secretory response in chromaffin cells that differs from the one induced by acetylcholine.
Assuntos
Células Cromafins , Células Cromafins/metabolismo , Polipeptídeo Hipofisário Ativador de Adenilato Ciclase/metabolismo , Exocitose/fisiologiaRESUMO
Researchers develop experimental platform that could be used to evaluate mutations and screen drugs for skeletal muscle diseases.
Assuntos
Cálcio , Músculo Esquelético , Músculo Esquelético/fisiologia , Mutação , Descoberta de DrogasRESUMO
JGP study suggests that Kv1 channels share a common mechanism of slow inactivation, but that some family members are less prone to inactivate than others.
RESUMO
JGP study reveals that adult zebrafish skeletal muscle fibers display the fastest kinetics of excitation-contraction coupling ever measured in vertebrate locomotor muscles.
Assuntos
Fibras Musculares Esqueléticas , Peixe-Zebra , Animais , Acoplamento Excitação-Contração , Fibras Musculares Esqueléticas/fisiologiaRESUMO
JGP study identifies a novel peptide in scorpion venom that inhibits KV1.2 and KV1.3 channels and could form the basis for new treatments for autoimmune diseases.
Assuntos
Venenos de Escorpião , Animais , Canal de Potássio Kv1.3 , Peptídeos , Bloqueadores dos Canais de Potássio/farmacologia , Venenos de Escorpião/farmacologia , Escorpiões , Linfócitos TRESUMO
JGP study uses both natural and unnatural amino acid substitutions to examine how a key tyrosine residue controls the selectivity of the Na+/K+ pump.
