The functional roles of feedback projections in the visual system.

Neurons in the nervous system make connections with ascending feedforward projections and descending feedback projections, as well as projections from neural structures at the identical hierarchical level. These neurons form extremely complicated neural networks and pathways. Compared with the role of the feedforward projection, much less is known concerning the functional roles of the feedback projection. Visual cortex is a good model for studying functional roles of cortical feedback projections which involve many high functions, such as attention, searching and cognition. The present review mainly focused on the functional roles of feedback projections in the visual system.

Visual functional changes during acute elevation of intraocular pressure.

Glaucoma is closely related to elevation of intraocular pressure (IOP). Many studies have done on the effect of chronic elevation of IOP on the retina and optic nerve, but less attention was paid to the effect of acute elevated IOP. Here we briefly review experimental studies on functional changes of the visual system from the retina to the visual cortex under acute elevated IOP condition, which is similar to that of acute primary angle-closure glaucoma.

[Accurate establishment of the retinotopic topography of area 17 in cats by intrinsic signal optical imaging].

The retinotopic topography of area 17 in cats was measured by optical imaging based on intrinsic signals. When stimulated with two neighboring gratings oriented orthogonally each other, which were positioned respectively in the upper and lower visual fields, one piece of cortex that had the retinal projection corresponding to the area around the border of the two stimulus gratings became blurred in the resultant function orientation map, because the neurons in this site received excitatory signals from both the horizontal and the vertical gratings via indirect ways. This functional map of the same cortex was compared with that elicited only by a horizontal or vertical grating stimulation in the whole visual field. Accordingly, the accurate position of the retinotopic eccentricity of the cortex in visual field can be demarcated by calculating the cross correlation coefficient of the two functional maps. Furthermore, compared with the electrophysiological measure of receptive fields of single cortical neurons, the retinotopic eccentricities revealed by optical imaging were identical. This experiment provides a fast and relatively accurate method to calculate the retinotopic eccentricities in a large cortical area of the visual cortex.