[Roentgenologic evaluation of myocardial contractility in heart valve diseases]. / Rentgenologicheskaia otsenka sokratitel'noi funktsii miokarda pri klapannykh porokakh serdtsa.

The authors compare the roentgenological findings with the parameters of contractility obtained during heart catheterization in 49 patients with mitral valvular disease and aortal valvular disease. The parameters are shown to be correlated with regard to the nature of valvular damage, characteristics of the impairment of the intracardiac hemodynamics and myocardial contractile function. Certain tendencies of this dependence are tabulated.

[Prostaglandins in the renal vascular bed in arterial hypertension of different etiologies]. / Prostaglandiny sosudistogo rusla pochek pri arterial'noi gipertonii razlichnoi étiologii.

Levels of PGE2, PGF2 alpha and renin activity were measured in renal venous blood of 29 patients with essential hypertension (EH), 23 patients with renovascular hypertension (RVH) and 10 patients with unilateral pyelonephritis and high arterial hypertension. The pattern of change in renal venous PG content was found to be related to the type of renal lesion: the level of PGE2 was lowered and PGF2 alpha/PGF2 ratio increased in the blood outflow from the kidneys of EH patients and from ischemized kidneys of RVH patients as compared to similar parameters in the outflow from contralateral kidneys of patients with RVH and pyelonephritis. Venous levels of both PGs were the highest in pyelonephritis-affected kidneys. Renal venous PG levels go down in all cases as the disease grows older. An acute drop in arterial pressure is accompanied with increased withdrawal of PGF2 alpha from the kidneys and enhanced renin activity in renal veins, while PGE2 drops simultaneously. PGF2 and PGE2 showing different trends of change in response to falling arterial pressure suggests increased transition of PGE2 to PGF2 alpha under the effect of enhanced PG-9-ketodehydrogenase activity. In the abdominal aorta, the scope of drop in arterial pressure correlates to the change in PGF2 alpha level, that is an evidence of PG direct involvement in the autoregulation of renal blood flow.

[Transcutaneous intravascular balloon dilatation in renal artery stenosis and arterial hypertension]. / Chreskoznaia vnutrisosudistaia ballonnaia dilatatsiia u bol'nykh so stenozom pochechnoi arterii i arterial'noi gipertenziei.

In 20 patients with stenosis of the renal artery and arterial hypertension Gruentzig balloon catheter was introduced transcutaneously into the artery with subsequent dilatation. In 2 cases arterial pressure became normal, in 8 the course of the disease improved, in 4 high hypertension was retained but responded to hypotensive agents, in 2 there was no effect, and in 4 balloon dilatation could not be carried out due to the impossibility of pushing the catheter through the stenosed segment of vessel. According to the data of renal scintigraphy plasma flow on the affected side rose by 16-66% after dilatation as compared to the initial figures, there was no significant change in the contralateral kidney.

[Separate and summary renal hemodynamics in renovascular hypertension (before and after surgery)]. / Razdel'naia i summarnaia pochechnaia gemodinamika pri renovaskuliarnoi gipertonii (do i posle operatsii).

It was found that hypertension in patients with stenosis of the renal artery is of a renopressor character which is maintained by increased renin secretion by the kidney with the stenosed artery. High arterial hypertension is conducive to the maintenance of the function of the kidney with the stenosed artery at the most optimum level and has an effect on the contralateral kidney. After surgery (nephrectomy), in addition to normalization of arterial pressure the blood flow in the remaining kidney becomes almost equal to the blood flow in two kidneys, i.e. the remaining kidney compensates for the function of the removed kidney. The incidence of malignant course of arterial hypertension in combination of an occlusive lesion of the renal artery and pyelonephritis of this kidney is twice that in isolated stenotic lesion of the renal artery.

[Renal hemodynamics, the renin-angiotensin system and prostaglandins in the malignant and stable course of arterial hypertension]. / Pochechnaia gemodinamika, renin-angiotenzinnaia sistema i prostaglandiny pri zlokachestvennom i stabil'nom techenii arterial'noi gipertonii.

The article discusses the results of the examination of 40 patients with symptomatic renal hypertension (in 15 of whom arterial hypertension followed a malignant course) and 19 patients with IIB-IIIA stages of hypertensive disease (6 of whom had the malignant form). Marked activation of the renin-angiotensin system along with reduced renal blood flow was found in patients with symptomatic renal hypertension. Despite the reduced renal blood flow, patients with the malignant form of hypertensive disease had diminished activity and secretion of renin as well as a considerably increased prostaglandin F2 alpha content and reduced sodium content in the plasma of renal venous and, particularly in the plasma of aortic blood.