1.
Bioorg Med Chem Lett
; 8(13): 1601-6, 1998 Jul 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9873398
RESUMO
MAdCAM-1 specifically binds the lymphocyte integrin alpha 4 beta 7 and participates in the homing of leukocytes to intestinal mucosal sites. The LDT sequence located on the CD loop of MAdCAM-1 is an important binding site for MAdCAM-1/alpha 4 beta 7 interactions. N-Terminus acylation of the LDT motif and modification of the C-terminus carboxamide with amines led to low micromolar MAdCAM-1 inhibitors.