[Changes in the serum biochemical indicators in healthy blood donors during cytapheresis]. / Vurkhu promenite na niakoi biokhimichni pokazateli v serumi na zdravi dariteli pri tsitofereza.

In the serum of 33 healthy donors to whom 72 cytophereses (31 thrombo-, 25 leuko- and 16 leukothrombocytophereses) were performed by a cell separator "Haemonetix 30" the following indices were followed up by SMA before and after the cytophereses: total protein, albumin, calcium, inorganic phosphorus, cholesterol, glucose, urea, uric acid, creatinine: total and conjugated bilirubin and alkaline phosphatase. Several of the donors were followed up dynamically. Immediately following the cytopheresis a transitory decrease of total protein, albumin, inorganic phosphorus and cholesterol was found. At the following cytopheresis of the same donor (the time interval between two cytophereses varied from 72 hours up to several months) the levels of the total protein, albumin, calcium, inorganic phosphorus and cholesterol had reached their normal values. The glucose level increased transitory though in the reference ranges.

[Changes in the plasma coagulation factors in patients subjected to plasmapheresis]. / Promeni na plazmenite faktori na susirane pri bolni, podlozheni na plazmafereza.

Eleven patients with immune-complex diseases were studied, that had been subjected to a total of 96 plasmaphereses during the day. The quantitative changes were followed up that developed in the active factors of coagulation after plasmapheresis. The results revealed that the plasma exchange, applied to the patients studied, induced the following changes: For factor I (fibrinogen)--mean = 2.39 +/- 1.19 g% (p greater than 0.005); for factor II (prothrombin)--mean = 55.5 +/- 20.9% (p less than 0.001); for factor V (proaccelerin)--mean = 97.6 +/- 13.8% (p greater than 0.01); for factor VII (proconvertin)--mean = 106.8 +/- 8.0% (p greater than 0.01); for factor VIII (AHG A)--mean = 64.5 +/- 22.7% (p less than 0.01); for factor IX (AHG B)--mean = 51.58 +/- 26.0% (p less than 0.001); for factor X--mean = 46.4 +/- 18.5% (p less than 0.001) and for factor XII--mean = 27.0 +/- 23.8% (p less than 0.001). That should be given consideration for the indications of the patients and their pretreatment for plasmapheresis.

[Search for embryonic antigens in the serum of leukemia patients]. / Tursene na embrionalni antigeni v serumi na levkozno bolni

The authors examined patients with blastic leucosis, myelosis and lympholeucosis for the presence of specific embrional antigens by immunodiffusion, using antisera, obtained after immunization of rabbits with extracts from human embryos and absorbed with tissue extracts from a normal adult. There were no specific embryonal components in the patients with leucemic sera or in the women from the control group.