[Effect of dalargin on repair capacity of gastroduodenal mucosa in patients with duodenal ulcer]. / Vliianie dalargina na reparativnuiu sposobnost' gastroduodenal'noi slizistoi obolochki u bol'nykh iazvennoi bolezn'iu dvenadtsatiperstnoi kishki.

Changes in the number of DNA-synthesizing nuclei of gastroduodenal mucosa in duodenal ulcer were monitored for patients treated with dalargin versus standard therapy (spasmolytics and antacids). In contrast to the standard treatment, dalargin 20-day administration produced a significant increase in the index of 3H-thymidine-labelled epithelial nuclei in fundal and duodenal bulb mucosa. The capacity for activating DNA synthesis in gastroduodenal mucosa may represent an essential mechanism of dalargin therapeutic action.