[Dynamics of changes in the protease-inhibitory balance in blood plasma of dogs with experimental acute pancreatitis]. / Dinamika izmenenii proteinazno-ingibitornogo balansa v plazme krovi sobak s éksperimental'nym ostrym pankreatitom.

Changes of proteinase-inhibitory system values in blood plasma of dogs with experimental acute pancreatitis (EAP) were studied in dynamics. Their diagnostic and prognostic values was appraised. Essential shifts were revealed in the proteinase-inhibitory balance in blood plasma of dogs with EAP of various severity. The concentration of trypsin- and chymotrypsin-like proteinases exceeded the normal values 1.8-3.3 times in these animals. Coefficients expressing the relation of antitryptic and antichymotryptic activities to the activities of the corresponding proteinases in the blood plasma of animals with EAP were indicative of diminished blood plasma inhibitory potential as compared to that in intact animals. The authors are the first to show the diagnostic and prognostic value of the antichymotryptic activity/chymotrypsin in blood plasma of dogs with EAP.

[Evaluation of the effectiveness of the use of specific hemosorption in acute experimental pancreatitis]. / Otsenka éffektivnosti ispol'zovaniia spetsificheskoi plazmasorbtsii pri éksperimental'nom ostrom pankreatite.

An effective method of plasma proteinases (trypsin, chymotrypsin. elastases) removal in dogs with acute pancreatitis has been suggested. The method is based on plasmasorption, using human urine acid-stable proteinase inhibitor immobilized on sepharose. The procedure of plasmasorption reduces proteinase levels in dogs with acute pancreatitis to 35-70%, with the animal life-span prolonged 8-fold.