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Purpose: Surgical resection has been traditionally used as a treatment for cavernous sinus hemangioma (CSH). However, this is usually difficult due to tumor vascularity and results in complications especially in large and giant CSH (volume >20 cm3). Previous studies have reported that radiotherapy (RT) provides an alternative treatment modality for hemangiomas. However, the optimized dose and fractions which control CSH and also protect the cognitive function remain unclear. This study reports our experience in the management of symptomatic large and giant CSH. Methods: Fifty-four patients with symptomatic large (20 cm3
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OBJECTIVE: To study the expression of serum sICAM-1 and sCD4 & sCD8 antigens in patients with nasopharyngeal carcinoma and clinical significances. METHOD: The serum levels of sICAM-1 and sCD4 & sCD8 antigens were determined in 54 patients with nasopharyngeal carcinoma (NPC group) and 32 healthy adults (normal group) by ELISA. RESULT: Expressions of serum sICAM-1 and sCD4 & sCD8 antigens in NPC group were significantly higher than that in normal group (P < 0.01, respectively). The levels of serum sICAM-1 in patients with III-IV stages were higher than those with I-II stages (P < 0.05), and those in patients with no lymph node metastasis lower than in lymph node metastasis (P < 0.01); but the serum levels of sCD4 and sCD8 antigens were not related to UICC-TNM stages in nasopharyngeal carcinoma (P > 0.05). The levels of serum sICAM-1 and sCD4 & sCD8 antigens decreased significantly in disappearance of tumor and metastatic lymph node after radiotherapy (P < 0.01). CONCLUSION: sICAM-1 might be involved in the cellular immunopathogenesis of nasopharyngeal carcinoma, and the measurement of the serum sICAM-1 and sCD4 and sCD8 antigens may reflect ability of neoplasm cell in freedom from host immunological surveillance. Dynamic measurement of serum sICAM-1 and sCD4 and sCD8 antigens may be a useful objective index to evaluate prognosis and curative effects of nasopharyngeal carcinoma.