RESUMO
OBJECTIVE: Using HPLC-ED or RIA, we determined simultaneously 15 indexes in 27 patients with the liver-blood deficiency syndrome (LDBD). By means of multivarivate hierarchical cluster analysis and selections of typical variate, the results showed that 15 indexes were classified into 5 groups, and the typical variates of each groups were NE, T3, TXB2, ALD and cGMP. It suggests that LBDS has some pathopysiological characteristics such as decreased functions of sympathetic nerve activation, lower T3 syndrome, imbalance of the active substance regulating cardiovascular function and metabolism of salt and water, and abnormalities second signal substance in cellular membrane.
Assuntos
Anemia Aplástica/sangue , Anemia Ferropriva/sangue , Deficiência da Energia Yin/sangue , Adolescente , Adulto , Idoso , Análise por Conglomerados , Diagnóstico Diferencial , Feminino , Humanos , Hepatopatias/sangue , Masculino , Medicina Tradicional Chinesa , Pessoa de Meia-Idade , Análise Multivariada , Norepinefrina/sangue , Tromboxano B2/sangue , Tri-Iodotironina/sangueRESUMO
AIM: To investigate the pathophysiology of erythrocyte energy metabolic changes of patients with the traditional Chinese Medicine (TCM) liver-blood deficiency syndrome (LBDS). METHODS: Erythrocyte membrane ATPase activity and oxygen consumption rate (OCR) were determined in 66 patients with LBDS, including 35 patients with iron deficiency anemia and 31 patients with chronic aplastic anemia. Thirty healthy adults served as controls. RESULTS: ATPase activity and OCR were decreased in patients with LBDS. CONCLUSION: The decreased erythrocyte ATPase activity and OCR might cause the energy hypometabolism in LBDS patients.
