[Correlation between HLA-DB1 genes and susceptibility to echinococcosis in Tibetan population in Tibetan Plateau].

OBJECTIVE: To determine the susceptibility genes and resistance genes in HLA-DRB1 alleles in Tibetan patients with cystic and alveolar hydatid diseases, so as to provide the references for the research of the genetic characteristics and infection mechanism of Tibetan hydatid diseases. METHODS: The case control method was applied. The Tibetan patients with cystic and alveolar hydatid diseases (63 and 73 cases respectively) in Yushu and Guoluo Tibetan Autonomous Prefecture, and unrelated healthy people (60 cases) in this area were selected as the study subjects. The polymerase chain reaction-sequence based typing (PCR-SBT) technique was applied for genotyping of HLA-DRB1, and the comparison of the gene frequency. RESULTS: The frequency of HLA-DRB1*04 in the alveolar/cystic echinococcosis group was lower than that in the control group ( χ2 = 4.71, 4.31, both P < 0.05). CONCLUSIONS: HLA-DRB1*04 genotypes may be associated with the resistance of cystic and alveolar echinococcosis and its resistance genes.

Efficacy of transoral CO2 laser microsurgery for early laryngeal cancer / 肿瘤

Objective: To explore the efficacy of transoral CO2 laser microsurgery in patients with early laryngeal carcinoma. Methods: Total of 186 patients with stages TisN0M0-T3N0M0 glottic or supraglottic laryngeal cancer between April 2003 and April 2008 were retrospectively collected. All of these patients received CO2 laser microsurgery. The clinical records and the follow-up information were analyzed. Results: The overall 3-year survival rate was 96.3%, 3-year local control rate was 87.7%, and 5-year local recurrence rate was 3.7%; the overall 5-year survival rate was 92.0%, 3-year local control rate was 77.8%, and 5-year local recurrence rate was 22.6%; the rate of lymph node metastasis was 9.1%. Conclusion: As the first choice for T1-2 glottic and supraglottic laryngeal cancer, transoral CO2 laser microsurgery can excise tumor correctly with the larynx being preserved, having a good long-term outcome. However, for advanced laryngeal cancer and supraglottic laryngeal cancer, transoral CO2 laser microsurgery should be carefully considered. Copyright © 2013 by TUMOR.