Estimating the burden of A(H1N1)pdm09 influenza in Finland during two seasons.

In Finland, the pandemic influenza virus A(H1N1)pdm09 was the dominant influenza strain during the pandemic season in 2009/2010 and presented alongside other influenza types during the 2010/2011 season. The true number of infected individuals is unknown, as surveillance missed a large portion of mild infections. We applied Bayesian evidence synthesis, combining available data from the national infectious disease registry with an ascertainment model and prior information on A(H1N1)pdm09 influenza and the surveillance system, to estimate the total incidence and hospitalization rate of A(H1N1)pdm09 infection. The estimated numbers of A(H1N1)pdm09 infections in Finland were 211 000 (4% of the population) in the 2009/2010 pandemic season and 53 000 (1% of the population) during the 2010/2011 season. Altogether, 1·1% of infected individuals were hospitalized. Only 1 infection per 25 was ascertained.

[Results of an endoscopic study in patients with long-term tubal dysfunction]. / Rezul'taty éndoskopicheskogo issledovaniia u bol'nykh s dlitel'noi tubarnoi disfunktsiei.

Basing on the findings of a comprehensive endoscopic examination of 121 patients with tubal dysfunction, a clinicoanatomic systematization was made of pathologic changes in the area of the pharyngeal opening of the auditory tube. A correlation was found between long-lasting tubal dysfunction and diseases of the nose, paranasal sinuses, nasopharynx and pharynx.

[Remote postoperative results of various surgical methodologies and the postop status of maxillary sinuses]. / Sostoianie verkhnecheliustnykh pazukh v otdalennom posleoperatsionnom periode pri razlichnykh variantakh saniruiushchei khirurgii.

The paper presents a comparative analysis of surgical outcomes in chronic maxillary ethmoiditis for radical and endonasal endoscopic operations in 85 patients. Objective control was performed with morphological, endoscopic and functional methods.

[Prevention of postoperative scars in otorhinolaryngology: experimental rationale]. / Eksperimental'noe obosnovanie profilaktiki posleoperatsionnykh rubtsovykh protsessov v otorinolaringologii.

It is demonstrated that in vitro inhibition of fibroblasts proliferation is feasible with the use of 5-fluorouracil. In stimulated growth of fibroblasts, the antiproliferative effect of 5-fluorouracil manifests even in a minimal concentration (2 mcg/ml). Recovery of fibroblast proliferative activity after elimination of 5-fluorouracil occurs in concentration under 63 mcg/ml.

[Prevention of postoperative scar processes in otorhinolaryngology experimental rationale]. / Eksperimental'noe obosnovanie profilaktiki posleoperatsionnykh rubtsovykh protsessov v otorinolaringologii.

It is shown in vitro that fibroblast proliferation may be inhibited by 5-fluorouracil (5-Fu). In stimulated growth of the fibroblasts the 5-Fu antiproliferative effect takes place even in minimal concentration (2 mcg/ml). Fibroblastic proliferative activity recovers after elimination of 5-Fu from the medium at concentration under 63 mcg/ml.

[Dysfunction of eustachian tube. New aspects of diagnostics and treatment]. / Disfunktsiia slukhovoi truby. Novye aspekty diagnostiki i lecheniia.

The authors review and provide a comparative assessment of diagnostic and treatment methods in acoustic tube dysfunction. New etiopathologically sound methods of treating long-term acoustic tube dysfunction are proposed. Therapeutic results are analysed for 36 patients with tuber dysfunction.

[Pilot experience with radio-knife "Surgitron"]. / Pervyi opyt ispol'zovaniia radionozha "Surgitron".

A new radiosurgical knife Surgitron is described in terms of its application in ENT operations. Surgical procedures, indications, operative regimes are detailed. Advantages and disadvantages of the device design are outlined. The device is functionally and cosmetically effective. Thus, it holds promise in surgery.

[Ligenten treatment of sinusitis]. / Primenenie ligentena v lechenii sinusitov.

Efficacy of local treatment with ligenten which was introduced after irrigation of the nasal sinuses was tried versus control intranasal introduction of 1% dioxidin solution. 35 and 25 patients with acute sinusitis or aggravation of chronic purulent sinusitis were treated, respectively. Subjective and objective responses in the study and control groups assessed with the use of sensor-analogue and visual-analogue scale demonstrated higher efficacy of ligenten.

[Characteristics of lymphocyte-monocyte-neutrophil interactions during varied-severity course of leptospirosis (a cytochemical study)]. / Osobennosti limfotsito-monotsito-neitrofil'nykh vzaimodeistvii pri raznoi tiazhesti techeniia leptospiroza (tsitokhimicheskoe issledovanie).

Correlations between neutrophilic enzymes (acid and alkaline phosphatases, myeloperoxidase, NBT test) and lymphocyte and monocyte enzymes (acid phosphatase, nonspecific esterase) were studied in 110 patients with icterohemorrhagic leptospirosis. These correlations were changing, depending on the disease severity and period. In case of a favorable course of leptospirosis in the initial period and at the peak a great number of intercellular correlations are formed between neutrophilic, lymphocytic, and monocytic enzymes. If the disease course is grave and complicated the intercellular relationships are ruptured at the peak of the illness. Convalescence is characterized by a gradual recovery of intracellular correlations.

[Temperature-dependent functional changes in sarcoplasmic reticulum membranes]. / Temperaturno-zavisimye funktsional'nye izmeneniia v mebranakh sarkoplazmaticheskogo retikuluma.

Temperature effect on changes in calcium ion transport and activity of Ca-ATPase of sarcoplasmic reticulum vesicles (SRV) was studied. Several temperature intervals of the change of SRV functional activity parameters were found: 8-12 degrees C-beginning of accumulation of SRV Ca2+, 12-19 degrees sharp activation of Ca2+ accumulation, 27-32 degrees-activation of passive yield, 36-43 degrees-reversible change of the activity of the accumulation system and activation of Ca yield, 48 degrees and higher--irreversible denaturation of transport Ca-ATPase. Coincidence of temperature intervals of SRV structural reconstructions, detected by means of fluorescent probes and functional changes points to a close relationship between structural reconstructions and functional responses of biological membranes.