1.
Chem Sci
; 15(9): 3249-3254, 2024 Feb 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38425521
RESUMO
A one-step approach to borylated cyclobutanes from amides of carboxylic acids and vinyl boronates is elaborated. The reaction proceeds via the thermal [2 + 2]-cycloaddition of in situ-generated keteniminium salts.
2.
Angew Chem Int Ed Engl
; 63(9): e202316557, 2024 Feb 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38251921
RESUMO
The spiro[3.3]heptane core, with the non-coplanar exit vectors, was shown to be a saturated benzene bioisostere. This scaffold was incorporated into the anticancer drug sonidegib (instead of the meta-benzene), the anticancer drug vorinostat (instead of the phenyl ring), and the anesthetic drug benzocaine (instead of the para-benzene). The patent-free saturated analogs obtained showed a high potency in the corresponding biological assays.