[Neurohumoral effect of xenon]. / Neirogumoral'nyi éffekt ksenona.

Clinical trials were carried out in 44 patients during cholecystectomies. The patients were divided into 2 groups (22 pts each) receiving (1) Xe:O2 (70:30) or (2) N2O:O2 (70:30) + phentanyl (0.1 ml boluses every 20 min). Neurohumoral parameters (ACTH, hydrocortisone, STH, prolactin, aldosterone, insulin) were almost identically activated in both groups. However, Xe monoanesthesia provided an anabolic pattern and better preserved the defense mechanisms of the organism in comparison with N2O + phentanyl anesthesia. Moreover, the STH/hydrocortisone ratio was 2-fold higher in the Xe group vs. N2O + phentanyl group. The activities of thyroid hormones (TSH, T3, T4) fluctuated within the normal range, which was indicative of adequate phases of anesthesia in both groups. The parameters of central hemodynamics and metabolism also indicated sufficient depth of anesthesia.

[Comparative assessment of the hormonal status during N2O and xenon anesthesia using similar methods]. / Sravnitel'naia otsenka sostoianiia gormonal'nogo fona pri odnotipnoi metodike anestezii N2O i ksenonom.

The hormonal status of 38 surgical patients during anesthesia with nitrous oxide and Xe administered by similar methods showed that in contrast to anesthesia with N2O, Xe anesthesia helped not only preserve the adaptive potential, but even increase the defense potential of the organism during surgery. Xe anesthesia was associated with a 1.5 times less requirement in fentanyl, with the levels of stress hormones being better; Xe is the best alternative to nitrous oxide.

[Hemodynamics and function of the myocardium during xenon anesthesia]. / Gemodinamika i funktsiia miokarda pri ksenonovoi anestezii.

Hemodynamics and phase structure of the cardiac cycle have been studied, using a technical complex "KO phi OOC", on 12 anesthesiologists volunteers during various stages of Xe anesthesia (70:30). During 30 min anesthesia Xe formed conditions for normalization of hemodynamic changes caused by emotional stress, had no depressive effect on the myocardium, failed to affect considerably vascular tone and myocardial phase structure. Due to its narcotic effect Xe changed variability of the cardiac rhythm.

[Clinical stages and subjective sensations in xenon anesthesia]. / Klinicheskia stadii i subektivnye oshchushcheniia pri ksenonovoi anestezii.

Clinical pattern of monoanesthesia with Xe:O2 (70:30) has been studied in 12 anesthesiologists volunteers in comparison with their subjective sensations. Four clinical stages of anesthesia have been identified: paresthesia and hypoalgesia, euphoria and psychomotor activity, analgesia and partial amnesia, anesthesia (analgesia and amnesia). Induction anesthesia took 5 to 6 min, anesthesia discontinuation was easy and prompt without any adverse events. In healthy men it was impossible to achieve complete amnesia with Xe:O2 (60:40). Subjective sensations from the anesthesia were pleasant. Xenone is the best alternative to N2O2.