RESUMO
The article deals with results of the study of functional condition of kidneys in newborns with congenital surgical pathology in the perioperative period. Serum cystatin C and urine ß2-microglobulin were used as a marker of acute kidney injury (AKI). The evaluation of parameters was given in dynamics--before and after surgery, and on 1st, 5th and 10th postoperative day. We analyzed prospects of using these markers in the diagnosis of AKI.
Assuntos
Injúria Renal Aguda/diagnóstico , Anestesia Geral/métodos , Anormalidades Congênitas/fisiopatologia , Anormalidades Congênitas/cirurgia , Rim/fisiopatologia , Injúria Renal Aguda/sangue , Injúria Renal Aguda/etiologia , Injúria Renal Aguda/urina , Biomarcadores/sangue , Biomarcadores/urina , Cistatina C/sangue , Humanos , Recém-Nascido , Testes de Função Renal , Período Perioperatório , Microglobulina beta-2/urinaRESUMO
The results of examinations of 66 newborns were used to suggest a new approach for evaluating the curves of medium urea molecules (calculations of the relative area beneath the curve and of areas of the first and second maxima). Issues related with the impact excreted by medication, endogenous intoxication and by a direct lesion to the renal tissues on a level of medium urea molecules are under discussion.
