Study on rhGM-CSF as adjuvant in revaccination among adults of non-and hyporesponders to hepatitis B vaccine / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>To investigate the effect of recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) as adjuvant on immune response in adults of non-and hyporesponders to hepatitis B vaccine.</p><p><b>METHODS</b>Those who were once immunized with recombined yeast gene hepatitis B vaccine more than one standard scheme in two years and negative for hepatitis B markers were randomly sorted as group A and group B. 33 adults of group A were given hepatitis B vaccine 10 microg each time. The immune procedure was 0, 1 and 6 month. 34 adults of group B were given rhGM-CSF 300 microg for the first day, then 10 microg each time for routine immune. The blood samples were collected before the first injection and in 1, 2 and 8 months (T1, T2, T8) following the first injection to test Anti-HBs.</p><p><b>RESULTS</b>Anti-HBs positive conversion rates of group A and B at T8 was 39.39% and 64.71% respectively (P = 0.038). Anti-HBs levels of group B at T1, T2, T8 were (113.85 +/- 198.56) mIU/ml, (312.40 +/- 349.44) mIU/ml, (427.74 +/- 411.58) mIU/ml (P = 0.001). There was significant difference between group A and B in T8 Anti-HBs levels (P = 0.010).</p><p><b>CONCLUSION</b>Better immune response was found in the group of rhGM-CSF with hepatitis B vaccine. So rhGM-CSF can induce the immune respond to hepatitis B vaccine.</p>

Effects of traffic exhausts on children' s neurobehavioral functions scored by neurobehavioral evaluation methods in Quanzhou, Fujian province / 中华流行病学杂志

<p><b>OBJECTIVE</b>To explore the effects of traffic exhausts on children's neurobehavioral functions.</p><p><b>METHODS</b>A field study was conducted in Quanzhou, Fujian province where two primary schools were chosen based on the numbers of automobiles passing by,and the data of ambient air pollutants from the monitoring system. School B and School A located at the high traffic exhausts pollution area and the clear area, respectively. Neurobehavioral functions of pupils in grade 2 and 3 were scored.</p><p><b>RESULTS</b>School B had very similar score of Ruiwen Test with School A, while the score of Digit Eras Test was lower than that in School A with marginal significance. The scores of Digit Symbol,Aim Tracing, Sign Register and Cormect Number test were 38.5 +/- 9.96, 84.3 +/- 27.83, 37.4 +/- 11.62 and 17.1 +/- 5.88 in School B,respectively, which were significantly lower than those in School A (41.6 +/- 12.97, 95.5 +/- 35.80, 42.3 +/- 15.58 and 18.7 +/- 5.78) respectively. Scores in Digit Symbol,Aim Tracing,Sign Register and Cormect Number of pupils in School B were 2.9, 11.5, 5.6 and 1.6 lower than those in School A after adjusting on other confounding factors.</p><p><b>CONCLUSION</b>It was suggested that traffic exhausts might cause damage to children's neurobehavioral functions.</p>