Assuntos
Aberrações Cromossômicas , Nêutrons Rápidos , Nêutrons , Adulto , Aneuploidia , Cromátides/efeitos da radiação , Exposição Ambiental , Humanos , Masculino , Pessoa de Meia-Idade , Poliploidia , Doses de Radiação , Lesões por Radiação/etiologia , Eficiência Biológica Relativa , Fatores de TempoRESUMO
The effect of a single insulin injection on the reaction of the coronary vessels to adrenaline, noradrenaline, and acetylcholine was studied in experiments on dogs. Insulin induces a decrease of arterial pressure and of the resistance of the coronary and peripheral vessels reduces the reflex cholinergic and beta-adrenergic reactions of dilatation of the coronary vessels, and promotes alpha-adrenergic reactions in intracoronary administration of adrenaline and noradrenaline. Insulin also weakens the immediate cholinergic reactions of the coronary vessels in stimulation of the effector systems with acetylcholine.
Assuntos
Vasos Coronários/efeitos dos fármacos , Insulina/farmacologia , Receptores Adrenérgicos/efeitos dos fármacos , Receptores Colinérgicos/efeitos dos fármacos , Animais , Circulação Sanguínea/efeitos dos fármacos , Pressão Sanguínea/efeitos dos fármacos , Pressão Venosa Central/efeitos dos fármacos , Cães , Feminino , Masculino , Fatores de Tempo , Resistência Vascular/efeitos dos fármacosAssuntos
Células da Medula Óssea , Exame de Medula Óssea/métodos , Medula Óssea/efeitos da radiação , Mitose/efeitos da radiação , Índice Mitótico/efeitos da radiação , Adulto , Idoso , Neoplasias da Mama/radioterapia , Feminino , Neoplasias dos Genitais Femininos/radioterapia , Humanos , Pessoa de Meia-Idade , Punções , Dosagem RadioterapêuticaRESUMO
Development of alloxan diabetes was accompanied in dogs by regular changes in the phasic structure of the cardiac contractions. Direction of the changes in the indices of phasic analysis in the groups of dogs with an average (up to 144.3 +/- 12.5 mg%) and marked (up to 258.0 +/- 22.8 mg%) increase in the blood sugar level was the same, but their expression increased with the elevation of hyperglycemia. In marked hyperglycemia there was established an increase (in comparison with normal values) of the index of myocardial tension, a shortening of the period of ejection, a decrease of the mechanical coefficient and of the intrasystolic index, this coinciding with the character of changes of the corresponding indices in the patients suffering from diabetes mellitus, depending on the severity of the disease. The data obtained pointed to the significant influence of metabolic changes (assessed by hyperglycemia level) on the contractile function of the heart.
