[The treatment of preasthma patients by inhalations of calcitrin]. / Lechenie bol'nykh predastmoi ingaliatsiiami kal'tsitrina.

Calcitrin inhalations were used in the treatment of 42 patients with preasthma (chronic obstructive bronchitis--37, asthmatic bronchitis--15). The antiinflammatory and chronic obstructive bronchitis. The broncholytic effect prevailed in patients with asthmatic bronchitis. There were no complications and side-effects due to calcitrin inhalations. Calcitrin inhalations are recommended in the complex treatment of preasthma.

[Various indicators of early diagnosis of the protracted course of acute pneumonia]. / Nekotorye pokazateli rannei diagnostiki zatiazhnogo techeniia ostroi pnevmonii.

Humoral immunity, body reactivity, reparative function of connective tissue were investigated in 45 patients with poor-symptom acute pneumonia and in 29 lingering pneumonia cases. The patients were examined for the content of IgM, IgG and IgA, haptoglobin, seromucoid, collagen metabolism (by oxyproline) on treatment days 1-5 and 15-25. With prolongation of the inflammation resolution and transformation of the disease into a lingering form, there appeared an imbalance of immunoglobulins manifested by low values of IgG and IgA. The latter immunoglobulins being the most active in body defences, this reflects disturbances in the mechanism of humoral immunity responsible for antiinfectious activity. Haptoglobin concentrations were of certain diagnostic significance, its level being higher in lingering pneumonia. In addition, oxyproline (total and bound) level rose thus evidencing catabolism predominance over collagen synthesis. This may underline delayed repair of the connective tissue in the lungs. Seromucoid, on the contrary, proved an unreliable sign. It is concluded that the level of immunoglobulins (IgG and IgA, in particular) as well as high blood haptoglobin and oxyproline with its components can be considered risk factors for poor-symptom pneumonia progression into a lingering one.

[Effect of calcitrin inhalation on the course of cortico-dependent bronchial asthma]. / Vliianie ingaliatsii kal'tsitrina na techenie kortikozavisimoi bronkhial'noi astmy.

Thirty-five patients with cortico-dependent bronchial asthma were treated with calcitrin inhalations during disease exacerbation. Calcitrin was administered daily for 10-12 days in the doses increased from 1 to 3-4 Units followed by reduction to the initial dose in the presence of routine therapy. According to the clinico-laboratory, spirographic and tachographic studies, the symptoms of asthma exacerbation rapidly degressed, while asphyxia attacks ceased or were relieved. The treatment with calcitrin made it possible to reduce the dose of steroid hormones by 25-50 percent on the average in 24 patients. In 11 patients, administration of the hormones could be discontinued. At the same time the majority of the patients demonstrated amelioration or elimination of the side effects induced by steroids (ossalgia, edema, gastralgia).

[Pharmacological correction of immunologic components in the combined treatment of chronic obstructive bronchitis]. / O farmakologicheskoi korrektsii nekotorykh zven'ev immunologicheskogo statusa v kompleksnom lechenii khronicheskogo obstruktivnogo bronkhita.

The authors provide comparative data derived during study of the time-course of changes in IgM, IgG and IgA and cellular eosinophilic and basophilic allergic reactions during application of pentoxyl and becotide alone and combined in multiple modality treatment of 161 patients with chronic obstructive bronchitis. Application of pentoxyl was accompanied mainly by quantitative increment of immunoglobulins, particularly IgA and IgG, and moderately pronounced desensitization effect that manifested by attenuation of the eosinophilic reaction and spontaneous degranulation of basophils. Application of becotide in multiple modality treatment led primarily to attenuation of the cellular allergic reactions under study and less marked increment of immunoglobulins. The combined use of the drugs for bronchitis exacerbation produced maximally pronounced desensitization (according to the eosinophilic reaction and basophil degranulation data) as compared to the effect of these drugs used alone on the patients' allergic status. It is recommended that patients with chronic bronchitis exacerbation should receive pentoxyl (during immunoglobulin deficiency and proneness to allergy), becotide inhalations to obtain primarily desensitization effect, and combined pentoxyl and becotide (in patients with high risk of sensitization).