RESUMO
1. The action of the extract from larvae of the great wax moth Galleria mellonella L. used in Russian folk medicine was studied. 2. Two active components influencing the growth and morphological differentiation of cells in vitro were found. 3. The presence of these components in the extract was conditioned by consumption of honeybee products by Galleria mellonella larvae. 4. Cytotoxicity of honeybee products was studied.
Assuntos
Abelhas/metabolismo , Medicina Tradicional , Mariposas/metabolismo , Extratos de Tecidos/farmacologia , Animais , Células Cultivadas , Humanos , Larva/metabolismo , Peso MolecularAssuntos
Bactérias/citologia , Látex , Técnicas Microbiológicas , Leveduras/citologia , MicroesferasRESUMO
A morphometrical study of cell ultrastructures of zona fasciculata of rat adrenal cortex was performed in norm and after immobilization during 4 or 24 hours. A 4 hour's immobilization (alarm reaction) is characterized by adrenocorticocyte activation: relative volumes of mitochondria and reticulum increase by 1.1 and 1.2 times, resp., and lipid volume decrease by 2.6 times. 24 hours after immobilization (the stage of maximal strain), mitochondrion and reticulum volumes decrease by 1.5 and 1.7 times, resp., compared to the initial ones, and autophagosome volumes increase sharply reaching 11% of the cytoplasm volume, i.e. this is the evidence of degeneration clearly registered morphometrically.