RESUMO
It is established that clofelin suppresses the human and dog insulin gastric secretion as well as human basal and histamine secretion. Clofelin has no effect on the secretory function of the dog stomach, stimulated by pentagastrin, carbachol histamine. It is supposed that clofelin-induced suppression of the human histamine gastric secretion takes place due to the inhibition of basal secretory component being a part of the common secretory effect on histamine. Clofelin may be promising drug in the treatment of patients with hypertension and duodenum ulcer.
Assuntos
Clonidina/farmacologia , Mucosa Gástrica/efeitos dos fármacos , Adolescente , Adulto , Animais , Cães , Interações Medicamentosas , Jejum/fisiologia , Suco Gástrico/efeitos dos fármacos , Suco Gástrico/metabolismo , Mucosa Gástrica/metabolismo , Humanos , Pessoa de Meia-Idade , Especificidade da Espécie , Fatores de TempoRESUMO
In chronic experiment on dogs it has been established that the subcutaneous injection of equimolar doses of izadrine (nonselective beta-adrenergic agonist), alupent (moderately selective beta 2-adrenergic agonist) and salbutamol (predominantly beta 2-adrenergic agonist) suppresses the pentagastric secretion approximately in the same degree. The blockade of beta-adrenoreceptors by the anapriline intensifies the gastric secretion stimulated by pentagastrin. All investigated adrenoactive agents didn't effect the dogs' histamine gastric secretion. In healthy men the activation of beta 2-adrenergic receptors by alupent accompanied by the expressed intensification of basal, pentagastrin and submaximal histamine gastric secretion. The blockade of these receptors by anaprilin decreases the gastric secretion. It has been concluded that only beta 2-adrenoceptors take part in the gastric secretion regulation. Considerable specific differences in the reaction of gastric glands on the activation of beta-adrenoreceptors are revealed: in human beings it leads to the excitation, in dogs--to the suppression of secretory cells.
