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1.
Transbound Emerg Dis ; 65(1): 135-145, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28299897

RESUMO

An appreciation of the costs of implementing canine rabies control in different settings is important for those planning new or expanded interventions. Here we compare the costs of three canine rabies control projects in South Africa, the Philippines and Tanzania to identify factors that influence the overall costs of rabies control efforts. There was considerable variation in the cost of vaccinating each dog, but across the sites these were lower where population density was higher, and later in the projects when dog vaccination coverage was increased. Transportation costs comprised a much higher proportion of total costs in rural areas and where house-to-house vaccination campaigns were necessary. The association between the cost of providing PEP and human population density was less clear. The presence of a pre-existing national rabies management programme had a marked effect on keeping infrastructure and equipment costs for the project low. Finally, the proportion of the total costs of the project provided by the external donor was found to be low for the projects in the Philippines and South Africa, but likely covered close to the complete costs of the project in Tanzania. The detailed economic evaluation of three recent large-scale rabies control pilot projects provides the opportunity to examine economic costs across these different settings and to identify factors influencing rabies control costs that could be applied to future projects.


Assuntos
Erradicação de Doenças/economia , Doenças do Cão/prevenção & controle , Raiva/veterinária , Animais , Análise Custo-Benefício , Doenças do Cão/economia , Cães , Humanos , Filipinas/epidemiologia , Densidade Demográfica , Raiva/economia , Raiva/prevenção & controle , Vacina Antirrábica/administração & dosagem , África do Sul/epidemiologia , Tanzânia/epidemiologia , Meios de Transporte
2.
Rev Sci Tech ; 37(2): 681-689, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30747117

RESUMO

Rabies is an economically important zoonosis. This paper describes the extent of the economic impacts of the disease and some of the types of economic analyses used to understand those impacts, as well as the trade-offs between efforts to manage rabies and efforts to eliminate it. In many cases, the elimination of rabies proves more cost-effective over time than the continual administration of postexposure prophylaxis, animal testing and animal vaccination. Economic analyses are used to inform and drive policy decisions and focus political will, placing economics at the heart of rabies control.


La rage est une zoonose importante au plan économique. Les auteurs décrivent la portée de l'impact économique de la rage et présentent quelques modèles d'analyse économique utilisés pour comprendre ces effets ; ils analysent également les compromis à trouver entre les efforts consacrés à la gestion de la rage et ceux dédiés à son élimination. Dans bien des cas, il est plus rentable sur le long terme d'éliminer la rage que de procéder à la gestion continue de la prophylaxie post-exposition chez l'homme et au dépistage et à la vaccination des animaux. Les analyses économiques servent à documenter et à orienter les décisions concernant les mesures à prendre afin de mobiliser la volonté politique nécessaire, en plaçant l'économie au coeur de la lutte contre la rage.


La rabia es una zoonosis que reviste importancia económica. Los autores exponen la magnitud del impacto económico de la enfermedad y algunas de las modalidades de análisis económico utilizadas para aprehender esas consecuencias, así como el juego de equilibrios entre las medidas de gestión de la rabia y las actividades destinadas a eliminarla. En muchos casos, la eliminación de la enfermedad ofrece a la larga mayor eficacia, en relación con el costo, que la continua labor de administración de profilaxis tras exposición, realización de pruebas en animales y vacunación de estos. Los análisis económicos sirven para fundamentar y encauzar las decisiones de planificación y para aglutinar la voluntad política, haciendo de los aspectos económicos un eje de la lucha contra la rabia.


Assuntos
Análise Custo-Benefício , Política , Vacina Antirrábica/imunologia , Raiva/veterinária , Animais , Erradicação de Doenças , Doenças do Cão/economia , Doenças do Cão/prevenção & controle , Cães , Humanos , Raiva/economia , Raiva/prevenção & controle , Vacina Antirrábica/economia , Zoonoses
3.
Transbound Emerg Dis ; 64(1): 121-129, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25885005

RESUMO

Rabies is endemic in the Philippines. In 2010, with support from the Bill and Melinda Gates Foundation, a canine rabies elimination project was initiated in the Philippine Archipelago of Visayan. We conducted an analysis of dog vaccination and human PEP costs for dog bite patients in a highly urbanized area and a low-income rural municipality in Cebu Province, Philippines, from 2010 to 2012. Our findings indicated that eliminating rabies in dogs through mass vaccination is more cost-effective than treating rabies exposures in humans. The average costs (in USD) per human life saved through PEP were $1620.28 in Cebu City and $1498 in Carmen. Costs per dog vaccinated ranged from $1.18 to $5.79 in Cebu City and $2.15 to $3.38 in Carmen. Mass dog vaccination campaigns conducted in each village were more cost-effective than fixed-site campaigns. The costs of dog vaccination can be reduced further through bulk vaccine purchase by the national government or large donor agency, for example the BMGF. As communities achieve canine rabies elimination, more judicious use of PEP will result in significant public savings. The study affirms the willingness of local governments to invest and reassure donors of their cooperation and resource contribution to sustain disease elimination efforts.


Assuntos
Análise Custo-Benefício , Erradicação de Doenças/economia , Doenças do Cão/prevenção & controle , Vacinação em Massa/veterinária , Vacina Antirrábica/economia , Raiva/veterinária , Animais , Cães , Humanos , Vacinação em Massa/economia , Filipinas , Raiva/prevenção & controle , Raiva/virologia
4.
Transbound Emerg Dis ; 64(3): 951-958, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26916104

RESUMO

An estimated 59 000 people die annually from rabies, keeping this zoonosis on the forefront of neglected diseases, especially in the developing world. Most deaths occur after being bitten by a rabid dog. Those exposed to a suspect rabid animal should receive appropriate post-exposure prophylaxis (PEP) or risk death. However, vaccination of dogs to control and eliminate canine rabies at the source has been implemented in many places around the world. Here, we analysed the vaccination and cost data for one such campaign in the area surrounding and including Dar es Salaam, Tanzania and estimated the cost per dog vaccinated. We also estimated the cost of human PEP. We found that the cost per dog vaccinated ranged from $2.50 to $22.49 across districts and phases, with the phase average ranging from $7.30 to $11.27. These figures were influenced by over purchase of vaccine in the early phases of the programme and the significant costs associated with purchasing equipment for a programme starting from scratch. The cost per human PEP course administered was approximately $24.41, with the average patient receiving 2.5 of the recommended four vaccine doses per suspect bite. This study provides valuable financial insights into programme managers and policymakers working towards rabies elimination.


Assuntos
Doenças do Cão/prevenção & controle , Custos de Cuidados de Saúde , Vacina Antirrábica , Raiva/veterinária , Animais , Mordeduras e Picadas/prevenção & controle , Doenças do Cão/epidemiologia , Cães , Humanos , Doenças Negligenciadas/epidemiologia , Doenças Negligenciadas/prevenção & controle , Raiva/epidemiologia , Raiva/prevenção & controle , Vacina Antirrábica/economia , Tanzânia/epidemiologia , Vacinação/economia , Zoonoses
5.
Transbound Emerg Dis ; 63(4): 408-15, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25414096

RESUMO

Rabies remains a significant problem throughout much of the developing world. An estimated 69 000 people die annually from exposure to rabies. Most of these deaths are the result of being bitten by a rabid dog. Mass vaccination campaigns targeting dogs have been implemented around the world in an attempt to control or eliminate canine rabies. We analysed the vaccination and cost data for a campaign in the KwaZulu-Natal province of South Africa; we found that the cost per dog vaccinated to be $6.61 for mass campaigns and $5.41 for local campaigns. We also estimated the cost of human post-exposure prophylaxis (PEP). The cost of PEP is approximately $64.50 on average per patient, and $333 on average for the 9% of patients who receive RIG. We also found that the districts that vaccinated the most dogs per capita experienced the highest rates of human treatment and thus had the highest PEP costs.


Assuntos
Mordeduras e Picadas , Doenças do Cão/prevenção & controle , Promoção da Saúde , Vacina Antirrábica/economia , Raiva/prevenção & controle , Animais , Cães , Humanos , África do Sul , Vacinação/economia
6.
Transbound Emerg Dis ; 62(4): 446-52, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24112194

RESUMO

We estimated the economic impacts of canine rabies in Latin America, Africa and Asia. Direct and indirect costs of rabies post-exposure prophylaxis, dog vaccination and control, rabies diagnostic testing and cattle mortality-related costs were accounted for. The number of human deaths was updated from previous estimates based on population growth, and the costs associated with the risk of human mortality were incorporated. We accounted for uncertainty associated with the parameter estimates using a Monte Carlo simulation and estimated that the global burden of canine rabies is approximately $124 billion annually. This result illustrates the potential benefits that could be realized if canine rabies was eliminated and provides an important benchmark against which the cost of any potential elimination campaign can be compared.


Assuntos
Efeitos Psicossociais da Doença , Países em Desenvolvimento/economia , Doenças do Cão/economia , Raiva/veterinária , África/epidemiologia , Animais , Ásia/epidemiologia , Bovinos , Doenças do Cão/prevenção & controle , Doenças do Cão/virologia , Cães , Custos de Cuidados de Saúde/estatística & dados numéricos , Humanos , América Latina/epidemiologia , Raiva/economia , Raiva/prevenção & controle , Vacina Antirrábica/economia , Vacinação/economia
7.
Transbound Emerg Dis ; 61(2): 140-6, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22984914

RESUMO

Vampire bat rabies causes significant impacts within its endemic range in Mexico. These impacts include livestock mortality, animal testing costs, post-exposure prophylaxis costs, and human mortality risk. Mitigation of the impacts can be achieved by vaccinating livestock and controlling vampire bat populations. A benefit-cost analysis was performed to examine the economic efficiency of these methods of mitigation, and Monte Carlo simulations were used to examine the impact that uncertainty has on the analysis. We found that livestock vaccination is efficient, with benefits being over six times higher than costs. However, bat control is inefficient because benefits are very unlikely to exceed costs. It is concluded that when these mitigation methods are judged by the metric of economic efficiency, livestock vaccination is desirable but bat control is not.


Assuntos
Doenças dos Bovinos/economia , Quirópteros/virologia , Surtos de Doenças/economia , Vacina Antirrábica/economia , Vírus da Raiva/imunologia , Raiva/veterinária , Vacinação/veterinária , Animais , Bovinos , Doenças dos Bovinos/prevenção & controle , Doenças dos Bovinos/virologia , Análise Custo-Benefício , Surtos de Doenças/prevenção & controle , Surtos de Doenças/veterinária , Reservatórios de Doenças/veterinária , Reservatórios de Doenças/virologia , México/epidemiologia , Raiva/economia , Raiva/prevenção & controle , Raiva/virologia , Vacina Antirrábica/administração & dosagem , Vacinação/economia
8.
Transbound Emerg Dis ; 60(4): 330-7, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22709550

RESUMO

Beginning in 2006, point infection control operations and aerial distribution of oral rabies vaccines along the US border were performed in Quebec, Canada, to control the potential spread of raccoon rabies. A benefit-cost analysis assessed the economic efficiency of this rabies control programme into the future. In this study, a mathematical simulation model was used to determine the potential spread of raccoon rabies from the 2006 index case, and incidence rates of human post-exposure prophylaxis (PEP), animal testing and human exposure investigations were calculated. Benefits were calculated as the potential savings from reduced numbers of human PEP, animal testing and human exposure investigations owing to control, which ranged from $47 million to $53 million. Programme cost scenarios were based on projections of total expenditures, which ranged from $33 million to $49 million. Economic efficiency was indicated for approximately half of the modelled scenarios, with the greatest benefit-cost ratios resulting from reduced future programme costs.


Assuntos
Controle de Doenças Transmissíveis/economia , Surtos de Doenças/veterinária , Modelos Econômicos , Vacina Antirrábica/economia , Raiva/veterinária , Guaxinins/virologia , Animais , Análise Custo-Benefício , Surtos de Doenças/economia , Surtos de Doenças/prevenção & controle , Humanos , Quebeque , Raiva/economia , Raiva/prevenção & controle , Vacina Antirrábica/uso terapêutico , Guaxinins/imunologia , Vacinação/economia , Vacinação/veterinária
9.
J Dairy Sci ; 95(11): 6820-9, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22981584

RESUMO

The objective of this producer survey was to identify and estimate damage caused by bird-livestock interactions in commercial dairies. The interactions between birds and livestock have previously been implicated in causing economic damage while contributing to the environmental dissemination of microorganisms pathogenic to livestock and humans. Very little research exists to help producers understand what bird species use dairies, why they use dairies, or the scope and nature of damage created as a result of bird-livestock interactions. To better characterize these interactions, we surveyed dairy operators within Pennsylvania, New York, and Wisconsin. Survey results suggest that the most common and destructive bird species found on commercial dairies are invasive to North America, and their use of dairies is associated with the loss of cattle feed, increased operating costs, and an increase in dairies self-reporting Salmonella spp. and Mycobacterium avium ssp. paratuberculosis. Cattle feed loss estimates generated from this survey were used to parameterize an input-output (IO) economic model using data from 10 counties in the state of Pennsylvania (Bedford, Berks, Blair, Bradford, Chester, Cumberland, Franklin, Lancaster, Lebanon, and Somerset). This IO model allowed us to estimate direct, indirect, and induced economic effects of feed loss from bird damage to dairies within these counties. The IO model output suggests that feed loss costs Pennsylvania between $4.11 and $12.08 million (mean $10.6 million) in total economic damage, with approximately 43 to 128 jobs (mean 112) forgone statewide in 2009.


Assuntos
Aves/microbiologia , Bovinos , Indústria de Laticínios/estatística & dados numéricos , Ração Animal/economia , Animais , Animais Selvagens/microbiologia , Doenças das Aves/economia , Doenças das Aves/etiologia , Doenças das Aves/microbiologia , Bovinos/microbiologia , Doenças dos Bovinos/economia , Doenças dos Bovinos/etiologia , Doenças dos Bovinos/microbiologia , Indústria de Laticínios/economia , Coleta de Dados/métodos , Mycobacterium avium subsp. paratuberculosis , New York , Paratuberculose/economia , Paratuberculose/etiologia , Paratuberculose/microbiologia , Pennsylvania , Salmonelose Animal/economia , Salmonelose Animal/etiologia , Salmonelose Animal/microbiologia , Wisconsin
10.
Zoonoses Public Health ; 58(3): 169-77, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-20819201

RESUMO

Ontario initiated a red fox (Vulpes vulpes) oral rabies vaccination (ORV) programme in 1989. This study utilized a benefit-cost analysis to determine if this ORV programme was economically worthwhile. Between 1979 and 1989, prior to ORV baiting, the average annual human post-exposure treatments, positive red fox rabies diagnostic tests and indemnity payments for livestock lost to rabies were 2248, 1861 and $246,809, respectively. After baiting, from 1990 to 2000, a 35%, 66% and 41% decrease in post-exposure treatments, animal rabies tests and indemnity payments was observed, respectively. These reductions were viewed as benefits of the ORV programme, whereas total costs were those associated with ORV baiting. Multiple techniques were used to estimate four different benefit streams and the total estimated benefits ranged from $35,486,316 to $98,413,217. The annual mean ORV programme cost was $6,447,720, with total programme costs of $77,372,637. The average benefit-cost ratios over the analysis period were .49, 1.06, 1.27 and 1.36, indicating overall programme efficiency in three of the four conservative scenarios.


Assuntos
Raposas , Vacina Antirrábica/economia , Raiva/veterinária , Administração Oral , Análise de Variância , Animais , Análise Custo-Benefício , Raposas/virologia , Humanos , Modelos Econométricos , Ontário , Profilaxia Pós-Exposição/economia , Profilaxia Pós-Exposição/estatística & dados numéricos , Raiva/economia , Raiva/prevenção & controle , Vacina Antirrábica/administração & dosagem , Estudos Retrospectivos
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