[Experience in treating a herpetic infection with trypsin]. / Opyt lecheniia gerpeticheskoi infektsii tripsinom.

Results are reported of trypsin treatment of 150 patients with herpetic infection (age of the patients: from 7 to 65 years). The results were compared with routine treatment in 200 patients. High efficacy of trypsin treatment as compared with routine treatment methods has been revealed. Trypsin treatment results in control of the pathological signs and symptoms not only in the acute period but also resulted in absence of recurrences of the infection and postherpetic neuralgia for 3 successive years. The efficacy of trypsin treatment has been thus established and the necessity of active detection and treatment of chronic carriers of herpetic infection by the proposed method is advocated.

[Various mechanisms of the pathogenesis and etiotropic therapy of neurologic forms of epidemic parotitis]. / Nekotorye mekhanizmy patogeneza i étiotropnaia terapiia nervnykh form épidemicheskogo parotita.

Immunoenzymatic, clinical and follow up study of 3500 patients suffering from nervous forms of epidemic parotitis was performed. It is concluded that the adaptive humoral enzymes, ribonuclease and trypsin, the persistence of antigen to epidemic parotitis virus in CSF lymphocytes as well as the immunologic status of the patient at the disease onset play the leading role in the pathogenesis of its acute phase. It advisable to examine the factors enumerated in order to predict the clinical course of the disease. The treatment with adaptive enzymes was of great efficacy in 660 patients.

[Pathogenesis of nervous system lesions in epidemic parotitis in children]. / K patogenezu porazhenii nervnoi sistemy pri épidemicheskom parotite u detei.

The authors studied antibodies to the nervous tissue in the blood (pair serum with an interval of 10 days) and in the CSF in 155 patients with epidemic parotitis and signs of neurotoxicosis, parotit meningitis and meningoencephalitis. Depending upon the intensivity of antibody elaboration 3 groups were distinguished. The first group (40 cases), with a high content of antibodies to the nervous tissue, was characterized by a prevalence of encephalitic forms (in 30 of the 40 cases). In the second group (32 cases) with a less antibody content there was a prevalence of meningitis, while meningoencephalitis was seen only in 3 cases. The third group (83 cases) with a low concentration or absence of antibodies was characterized by a mild course of the disease. This group included as well patients with neurotoxicosis. These data may indicate involvement of allergic mechanisms of a retarded type in the pathogenesis of remote lesions of the nervous system in epidemic parotitis.