[Assessment of the deficiency in the T3 pool in hypothyroidism]. / Otsenka defitsita pula T3 pri gipotireoze.

The leading role of the endocellular ways in the T3 formation among the thyroid hormones was revealed. Therefore new approaches to the evaluation of thyroid function disorder are required. On the basis of the radioimmunoassay the authors have devised a new method of the determination of quantitative deficiency of the T3 pool in the body. The author present the first results of its use in clinical practice for the evaluation of the severity of hypothyroid conditions and control over the efficacy of hormonal substitution therapy.

[Characteristics of the amino acid spectrum of blood serum in diabetes mellitus]. / Osobennosti aminokislotnogo spektra syvorotki krovi pri sakharnom diabete.

The content of the following 10 amino acids was investigated by means of a microbiological method (with the use of auxotrophic E. coli mutants) in 23 patients with diabetes mellitus with fatty infiltration of the liver and in 27 patients without it: histidine, proline, methionine, cystine, tryptophane, leucine, arginine, tyrosine, lysine, and phenylalanine. Results of study of the amino acid balance were compared with the morphological changes in the liver (the material was obtained by biopsy). All the diabetic patients displayed an increase in the proline, tryptophane, tyrosine, leucine, and cystine content, and a reduction of phenylalanine and lysine level. Fatty hepatocyte infiltration was also accompanied by a significant elevation of methionine and a reduction of arginine content. A tendency to normalization of leucine and lysine only was seen after the treatment of diabetic patients with fatty hepatocyte infiltration; diabetic patients without any fatty infiltration showed normalization in the tyrosine, lysine content and a tendency to the normalization of the cystine, tryptophane level, but no change in the methionine content.